Glioma (glioblastoma) accounts for about 46% of intracranial tumors and 1% to 3% of systemic malignant tumors. The average survival period for surgery plus radiotherapy is only 8 to 11 months, and so far there is no long-term follow-up information for large cases of glioma in China. In 1998, the World Health Organization announced that malignant glioma was the second cause of death for patients under 34 years of age and the third cause of death for patients between 35 and 54 years of age in order of mortality. Globally, malignant glioma mercilessly takes the precious lives of 180,000 to 600,000 young and middle-aged people every year. 1. Occupancy effect Causes increased intracranial pressure, headache is most common. In addition, there is vomiting and optic disc edema. 2.Local dysfunction. 3.Epilepsy: 1/3 patients have epilepsy as the first symptom. Treatment: Currently, comprehensive treatment is advocated, i.e. surgery + radiotherapy + chemotherapy.