In patients with AKI, renal damage is only one aspect of the disease, but the systemic internal environmental disturbances and comorbidities that result from AKI are often important factors in accelerating the progression of the disease. Therefore, the core of APD treatment is to provide a supportive therapy, which is reflected in the correction of metabolic disorders and the maintenance of volume and electrolyte balance in the body, in order to protect the function of the heart, brain, kidney and other important organs. Therefore, the following issues should be noted in the process of APD application. Early implementation of PD Most AKI is often combined with hemodynamic disturbances, and this abnormal state will worsen as the disease progresses and cause a series of comorbidities. Therefore, early implementation of PD can not only improve the metabolic disorder but also help maintain the hemodynamic stability of the organism. Second, reasonable choice of dialysis mode and dose AKI is completely different from end-stage renal failure, in addition to progressive renal impairment, the metabolic state and nutritional balance of the body are very different from the latter, therefore, it is not appropriate to copy the treatment mode of CRF. The dialysis regimen should be individualized according to the patient’s size, metabolic status, and residual renal function status. The dialysis pattern and dose should be adjusted according to daily blood biochemical and physiological (weight, central venous pressure, urea KT/V, etc.) parameters. It is worth pointing out that in clinical practice, the main basis for judging the change of disease is the rise and fall of blood creatinine, which is in fact completely unreasonable. Blood creatinine is strongly influenced by diet and metabolism, which can be misleading in the case of AKI. In addition, it is more important to maintain the volume balance in the body during the treatment of AKI, so this factor should be taken into account when choosing the dialysis mode. APD requires a high flow rate and flow of dialysis fluid, so dialysis catheters should be selected with as many side holes as possible and with a certain amount of tension, such as SWANNECK convoluted tubing. Prevention of dialysis-related comorbidities AKI patients have more entrapment, and the resistance of these patients is weaker, so some dialysis-related comorbidities, especially infections, are easily caused during APD treatment. In addition, APD can also affect the lung function of patients who are mechanically ventilated. In conclusion, PD is unique in its ability to protect residual renal function and maintain the stability of the body’s internal environment. Compared with other CRRTs, PD is not only technically simple, easy to perform, and inexpensive, but also can be used at home, making it the preferred treatment for patients with mild to moderate AKI.