Chinese medicine treatment for liver cancer

  Primary hepatocellular carcinoma (abbreviated as hepatocellular carcinoma) is a cancer that occurs in hepatocytes and intrahepatic bile duct cells, and is one of the most common malignant tumors with high morbidity and mortality in China. It is one of the most common malignant tumors in the world and has a high morbidity and mortality rate in China. It is characterized by high malignancy, rapid disease progression and short survival period. Despite the continuous improvement of early diagnosis technology and treatment methods, the efficacy of liver cancer is still extremely poor, and the short survival period and the ease of metastasis and recurrence seriously threaten the physical and mental health of human beings. This disease can be classified as “obstruction,” “accumulation,” “dropsy,” “jaundice,” “jaundice,” and “jaundice” in traditional Chinese medicine. It can be classified as “obstruction,” “accumulation,” “dropsy,” “jaundice,” “hypochondriasis,” “biliary distension,” “fullness,” and “rock,” etc., which have been paid more attention to its prevention and treatment by traditional Chinese medicine practitioners. Modern Chinese medicine has made great progress in the research of hepatocellular carcinoma, and Chinese medicine treatment is playing an increasingly important role in the comprehensive treatment of hepatocellular carcinoma.  The experiments on the prevention of oncogene initiation by Chinese medicine have shown that many Chinese medicines (such as Astragalus, Atractylodes, Hesperus, Panax notoginseng, Panax notoginseng, Salvia divinorum, Rhizoma, asparagus, peach kernel, red salvia, raw oyster, etc.) have anti-mutagenic effects. Studies at the cellular level have confirmed that Zhi Bai Di Huang Wan and Zuo Gui Wan have anti-mutagenic and anti-carcinogenic effects, and Tian Ji Huang, Weifang Cao, Gan Cao and Bai Quai Cai have anti-cancer, anti-inflammatory and detoxifying effects. Modern pharmacological studies have shown that Sargassum has an inhibitory effect on DNA synthesis in liver cancer cells; Half-branch lotus, White flowered snake tongue herb, Augusta, Astragalus, Green tea and Rhizoma have different degrees of anti-cancer gene mutation effect, which can protect DNA of lymphocytes and protect the immune system from destruction.  It is generally believed that hepatocellular atypical hyperplasia, adenomatous hyperplasia, hepatocellular regenerative nodules, hepatocellular tubular hyperplasia and oval cell hyperplasia occurring in chronic liver disease are closely related to hepatocellular carcinogenesis and are considered to belong to the category of hepatocellular precancerous lesions. If the pathological process of hepatocellular precancerous lesions can be reversed or interrupted, the occurrence of hepatocellular carcinoma can be effectively prevented. In recent years, studies on precancerous liver lesions have shown that Western medicine still lacks ideal means to interrupt or reverse the lesions, while the preventive and curative effects of Chinese medicine are highly anticipated and have become the focus of current research on liver cancer prevention and treatment. There is no specific name for precancerous liver lesions in ancient Chinese medicine. Because of its pathogenetic characteristics, it is mostly classified as accumulation, dropsy, dystrophy, and liver pain. According to Chinese medicine, when dampness, heat, epidemic and poison invade the human body, they mostly injure the spleen and stomach first. Emotional and mental disorders lead to loss of drainage of the liver, unfavorable qi flow, and finally loss of harmony between the internal organs. If the disease is prolonged, the evil power is not decayed, but the positive qi has been injured. During the whole pathogenesis, spleen deficiency is always present as one of the pathological bases, and the main pathological mechanism is the interplay of phlegm, stasis and toxicity due to the disorder of liver and spleen.  Experimental and clinical observations show that the occurrence, development, treatment effect and prognosis of malignant tumors are all related to the immune status of the body to a certain extent. Therefore, improving the immune function of the body undoubtedly has a certain inhibitory effect on the occurrence and development of cancer. Therefore, the focus of medical practitioners and one of the basic treatment rules of TCM is to support and cultivate the root, so as to achieve the purpose of “treating the disease before it occurs”. Some traditional Chinese medicines, such as Radix et Rhizoma Ginseng, Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis Macrocephalae, Rhizoma Acute, Rhizoma Longifolia, etc., can enhance the immune function of the body and have the effect of supporting the righteousness and fighting against cancer. Guan Yang et al. found that the natural killer cell (NK cell) activity of rats taking chaste Qi Fu Zheng capsule for 8 weeks plus the chemical carcinogen diethylnitrosamine (DEN) was significantly higher than that of rats taking carcinogen alone; the serum concentrations of interleukin 2 (IL I2) and tumor necrosis factor (TNF) tended to increase compared with the carcinogen group alone, and the toxic damage to liver by DEN was significantly lower than that of other experimental groups, suggesting that Ray et al. Grape seed extract (GSPE) proanthocyanidins reduced the rate of hepatocarcinogenesis and mortality in dimethylnitrosamine (DMN)-induced B6C3F1 mice by modifying the metabolic cascade and regulating the multilevel cell death program of tumorigenesis, and reduced the number of tumors in mice.  2. Prevention of recurrence after surgery Comprehensive treatment is the better plan for the treatment of tumors at this stage, and is the basic principle of most tumor treatments at present. Early radical resection has a better 5-year survival rate, however, the high recurrence rate is the bottleneck to improve its long-term efficacy. The synergistic effect of TCM can improve the immune function of the body, reduce the recurrence rate and improve the quality of life of patients. The current focus on postoperative hepatocellular carcinoma is mainly on preventing recurrence and improving quality of life, but through the collation of literature, we found that there are several problems: (1) There is no unified standard for clinical identification, and there are few identical types of identification among medical doctors, and the specific names of the evidence are also very confusing. The reason for this is that many physicians are mainly using the pattern of compound evidence for the identification and typing of primary liver cancer. This model not only causes confusion in the names of the evidence, but also affects the differentiation of the primary and secondary symptoms.  (2) In general, there is still a lack of systematic research and a complete treatment system has not been formed, which is not conducive to the promotion of application, and this also reflects that the clinical combination of Chinese and Western medicine is not deep enough.  Patients with hepatocellular carcinoma after microwave thermal ablation therapy were classified into five types of evidence, including Qi stagnation and blood stasis evidence, damp-heat inclusion evidence, spleen deficiency and dampness trapping evidence, liver depression and spleen deficiency evidence, and liver and kidney yin deficiency evidence. Zhang used the tumor-eliminating soup (half-branch lotus, half-sided lotus, stone see-through, vine pear root, white ying, lobelia, and white flower and snake tongue grass) to treat patients with hepatocellular carcinoma after hepatic artery chemoembolization. From the pharmacological analysis, Hesperidin and Hesperidin have certain inhibitory effects on sarcoma, Ehrlich ascites carcinoma and brain tumor, and the inhibition rate of tumor cell proliferation is over 90%; the extract of Hesperidin 1mg can kill all liver cancer cells in 0 and 2ml ascites within 24h, and has inhibitory effects on cervical cancer, solid type of liver cancer and Ehrlich ascites carcinoma; Baiying and Longkui are more effective on cancerous thoracic ascites and It has a significant inhibitory effect on the proliferation of liver cancer cells, and its inhibition rate can be 87, 35%; vine pear root can block the synthesis of carcinogenic nitrosamines and promote the production of interferon, which has anti-cancer effects, and stone see through can inhibit or kill all kinds of cancer cells and enhance immune function. We also found in observing the anti-tumor efficacy that even for patients with advanced tumors with lack of treatment, it has the effect of improving symptoms, inhibiting tumor multiplication and prolonging life.  According to Chinese medicine, the causes of liver cancer are internal and external. The internal causes are mainly the lack of healthy spleen due to fatigue and spleen injury, or the loss of drainage of liver due to depression. The external causes are mainly internal invasion of dampness, heat and toxicity to the liver, gallbladder, spleen and stomach, or excessive consumption of tobacco and alcohol to produce dampness and heat and toxicity to the liver, gallbladder, spleen and stomach. The pathogenic mechanism is positive deficiency and evil actuality, with positive deficiency mostly in liver and spleen and evil actuality mostly in dampness, heat, stasis and toxicity.  The mechanisms of action of Chinese medicine on liver cancer are: (1) certain drugs have certain cytotoxic effects on cancer cells, which can kill and inhibit liver cancer cells; (2) anti-cancer potentiation and protection of normal cells; (3) anti-mutagenic effects; (4) inhibition of tumor metastasis.  Commonly used clinical drugs include: (1) Diversifying the liver and strengthening the spleen: Chai Hu, Buddha’s hand, Prince’s ginseng, Poria, Chen Pi, Radix Paeoniae Alba, Paeonia lactiflora, Yan Hu Suo, Citrus aurantium, Hou Pu, Aromatic herb, Yu Jin, Daji Pi, Yam, Tortoise, Cornus officinalis.  (2) Invigorating blood circulation and resolving blood stasis: San Leng, Curcuma longa, Shi Mian Dian Dian, Ping Di Mu, San Qi, Red Peony, Dan Shen, Wang Bu Li Xing, etc.  (3) Nourishing yin and nourishing blood: Southern ginseng, Northern ginseng, asparagus, Dendrobium, Radix et Rhizoma, Radix et Rhizoma, Radix et Rhizoma, Radix et Rhizoma, Radix et Rhizoma, Radix et Rhizoma, Radix et Rhizoma, Radix et Rhizoma, Radix et Rhizoma, etc.  (4) Clearing away heat and detoxifying toxins: Chonglou, Half-branch lotus, Half-sided lotus, Sulforaphane, Dandelion, Forsythia, Panax quinquefolium, Yin Chen, Lungwort, Sanguisorba, Mountain ciliate mushroom, Snake berry, Dongling grass, Scutellaria, etc.  Thirty cases of hepatocellular carcinoma were treated with Tianjihuang. The results showed significant improvement in clinical symptoms and laboratory tests, including 8 cases each of B ultrasound and CT examination turned negative after treatment. Zheng Guocan et al. found that Tanshinone I had the effect of inhibiting cell growth and blocking HepG2 cell cycle in G0/G1 phase, and could induce apoptosis of HepG2 cells by down-regulating bcl-2 gene expression and up-regulating bax gene expression through in vitro experiments on human hepatocellular carcinoma cells (HepG2). It was found that ginsenoside Rg3 not only significantly inhibited the growth of tumor cells in HepG2 mice, but also induced apoptosis of tumor cells, significantly increased the killing activity of NK cells and macrophages in HepG2 mice, and induced the activation of IL-12 and TNF-α produced by macrophages to exert tumor suppressive effects. Ginsenoside Rg3 has obvious anti-tumor effect which can enhance the anti-cancer and lymphatic tract metastasis inhibiting effect of chemotherapy drug PDD and improve the immune function of HoH22 mice. Experiments have shown that those who commonly use traditional Chinese medicine can reduce the incidence of pain in liver cancer patients and reduce the application of morphine-based analgesic drugs. It can make advanced liver cancer patients eliminate fatigue, reduce pain, increase appetite, prolong life and greatly improve patients’ quality of life.  Chinese medicine treatment and combined Chinese and Western medicine treatment are the characteristics of China and have been playing a unique advantage in anti-tumor treatment. With the modernization and development of Chinese medicine, Chinese medicine treatment methods themselves are gradually colorful, and in the whole process of tumor treatment, Chinese medicine theory is used as the guide to discriminate and treat, and various existing treatment methods are applied in a planned and rational manner to maximize the overall treatment advantages of Chinese medicine and restore the organism The aim is to improve the sensitivity of radiotherapy and chemotherapy, minimize toxic side effects, reduce tumor metastasis and recurrence, completely cure tumor patients who have received radical treatment, improve the quality of life of advanced tumor patients, and prolong the survival period with tumor.