Non-concave mucinous edema is the characteristic clinical response to thyroid hormone deficiency in adults. Primary hypothyroidism (hypothyroidism) is the most common type and is probably an autoimmune disease. It usually occurs as a result of Hashimoto’s thyroiditis and is often accompanied by a firm enlarged thyroid gland, which later develops as the disease progresses to a shrunken, fibrous thyroid with no or little function. The second most common type is post-treatment hypothyroidism, especially due to hyperthyroidism with radioactive iodine and surgical treatment, propylthiouracil, tabazol and iodine overtreatment of hypothyroidism, which often recovers after termination of treatment, and mild hypothyroidism commonly seen in older women. So how is non-concave mucinous edema diagnosed? Here’s what you need to know. Clinically, non-sunken mucinous edema has an insidious onset and slow course and is not easily detected in the clinic. It often manifests as fear of cold, eyelid edema, weight gain, constipation, abdominal distension, and, in severe cases, pericardial effusion, cardiomegaly, cardiac failure, coma, and even hypothyroid crisis. Alzheimer’s disease may also develop in the elderly. Some patients have atypical early symptoms of non-sunken mucinous edema, and must be aware of the following symptoms: 1. loss of appetite, reduced food intake, bloating and constipation; 2. anemia; 3. decreased libido and menstrual irregularities; 4. muscle hypertrophy, flaccidity, and slow movement; 5. bradycardia, low voltage or with T-wave hypo-equality; 6. slow and slurred speech and dull tone; 7. skin pale, cool and dry, mucous edema of the skin of the hand and lid, concave in the early stage, non-concave in the late stage, thin and dry hair, brittle nails; 8, slow reaction and memory loss.