Non-concave mucinous edema is the characteristic clinical response to thyroid hormone deficiency in adults. Primary hypothyroidism (hypothyroidism) is the most common type and is probably an autoimmune disease. It usually occurs as a result of Hashimoto’s thyroiditis and is often accompanied by a firm enlarged thyroid gland, which later develops as the disease progresses to a shrunken, fibrous thyroid with no or little function. The second most common type is post-treatment hypothyroidism, especially due to hyperthyroidism with radioactive iodine and surgical treatment, propylthiouracil, tabazol and iodine overtreatment of hypothyroidism, which often recovers after termination of treatment, and mild hypothyroidism commonly seen in older women. So what is the preventive treatment for non-concave mucinous edema? Here’s what you need to know. There are a number of thyroid hormone preparations that provide replacement therapy, including T4 (levothyroxine), 3 iodothyronine (Liothyronine), a mixture of both hormones and dried thyroid powder from animals. Synthetic T 4 (levothyroxine) is better, with an average maintenance dose of 75-125 μg/d orally, but the starting dose must be low, especially in elderly patients with cardiac disease and in patients with chronic severe hypothyroidism (unless in mucinous edema coma). Absorption is fairly constant at about 70% of the dose.T3 is produced from peripheral tissues. The maintenance dose can be reduced in the elderly and increased in pregnant women. The dose should also be increased if concomitantly administered with drugs that reduce T4 absorption or increase excretion in the bile. See Section 269 Hypothyroidism for dosing in infants and very young children. The most appropriate dose should be the smallest dose that restores TSH to normal (although this criterion does not apply to secondary hypothyroidism).