Department of Endocrinology, Wuhan Union Medical College Hospital Thyroid nodules are common diseases in endocrinology. The prevalence is 30-40% in adults, and more than 95% of them are benign nodules, most of which do not require surgical treatment. Studies have confirmed that ultrasound-guided fine-needle aspiration has a higher diagnostic yield for thyroid nodules than standard fine-needle aspiration biopsy. In addition, the efficacy of current pharmacological treatment for non-functioning thyroid nodules is uncertain. In contrast, ultrasound-guided percutaneous anhydrous alcohol injection sclerotherapy for thyroid nodules causes pathological changes such as dehydration, degeneration, and coagulative necrosis of local tissue cells due to anhydrous alcohol, which leads to shrinkage or disappearance of nodules. This method has been generally accepted by the international medical academic community because of its small trauma, high accuracy and positive efficacy. Since this technique was carried out in 2010, the Department of Endocrinology of Union Hospital has achieved good results in more than ten cases of cystic or solid thyroid adenomas and nodules, and accumulated a lot of successful experiences, and further adopted targeted doses for the treatment of thyroid nodules according to their size and nature, bringing gospel to the majority of patients with thyroid nodules. Lulu Chen, Department of Endocrinology, Wuhan Union Medical College Hospital