Brain damage may occur during the neonatal period for a variety of reasons. Common types of etiologies include fetal or postnatal asphyxia hypoxic-ischemic encephalopathy, paraventricular leukomalacia in premature infants, cerebral infarction, hypoglycemic encephalopathy, and metabolic encephalopathy. Abnormal limb signs often appear in early infants, such as difficulty in erecting the head, thumb inversion, limb hypertelorism, corneal inversion, and retardation in light and object tracking, should attract sufficient attention from parents. The clinical manifestations of brain injury can vary from site to site, so it is important to achieve early detection, early diagnosis and early intervention. We cannot change the reality of brain injury, but the developmental trajectory of the child can be reversed through the joint efforts of doctors and parents, and regular neurological monitoring and follow-up with experienced doctors is needed to care for the healthy growth and progress of the child. Brain injury cortical damage secondary to epileptic seizures in infancy and childhood is a common complication. The mechanism is due to damage to the cerebral cortex, in the process of repair and growth, the cortex appears abnormal discharge, clinical manifestation of convulsive seizures; seizures in various forms, varying degrees, easy to attract the attention of parents, these application of antiepileptic drug treatment, the symptoms are more easily controlled. When the cortical discharges are less frequent, or the seizures are insidious and atypical, or subclinical, it is not easy for parents to detect them in their care, which will affect the child’s cognitive progress for a long time and interfere with the rehabilitation effect, resulting in the failure to fully develop the brain potential. For a long time, domestic and foreign colleagues have conducted a lot of exploration in this field, and the six words “early, comprehensive and persistent” are the central principles of neurorehabilitation treatment. In the early stage of neonatal life, when the child’s vital signs are stable, the child can start to receive comprehensive neurorehabilitation treatment, which can achieve twice the effect with half the effort. GM1 is a heterogeneous sialic acid-containing membrane glycolipid, whose molecule consists of a hydrophobic ceramide part and a hydrophilic sialic acid oligosaccharide group. GM1 is a heterogeneous group of sialic acid-containing membrane glycolipids, whose molecules consist of a hydrophobic ceramide part and a hydrophilic sialic acid oligosaccharide moiety, with the trans-amide part inserted into the membrane lipid and the carbohydrate part exposed on the cell surface. protective agent has achieved significant efficacy in the treatment of adult stroke, peripheral neuropathy, and Parkinson’s disease. Promotes nerve regeneration and recovery. Promotes nerve regeneration and recovery. Specific application: 20mg/day, diluted intravenous drip, once daily, every 14 days as a course of treatment, the next course of treatment is 4-6 weeks apart, three courses of treatment can be completed within six months, vitamin B and nerve growth factor can be applied in combination. Note: It is prohibited for children with seizures or extensive abnormal EEG discharges to avoid inducing and aggravating seizures. 2, hyperbaric oxygen therapy: HBO therapy is one of the important methods of comprehensive treatment, its mechanism of action is to increase the partial pressure of blood oxygen, improve tissue oxygen supply, improve brain tissue metabolism, promote the repair of damaged brain tissue and neurological recovery, improve microcirculation, inhibit platelet and red blood cell aggregation, and reduce blood viscosity, reduce thrombosis, and ensure smooth cerebral microcirculation. The main reason is that HBO has the property of improving the permeability of blood vessel wall and promoting the chemical drugs already in the blood to pass the blood-brain barrier, which has a synergistic effect with GM1. 3. Motor function training: For those who have motor (gross and fine motor) dysfunction, our pediatric neurological rehabilitation center’s movement room is dedicated to assessing and formulating individualized rehabilitation training programs using Vojta induction therapy or Boabath neurodevelopmental therapy, and the treatment is carried out by a full-time therapist. During the rehabilitation process, touching the infant is a benign stimulus to the infant by stimulating the skin touch and pressure receptors to input perceptual information via nerve endings, which can effectively reduce the sequelae of HIE; doing baby exercises, swimming and other motor rehabilitation methods can regulate muscle tone, improve sensory perception, correct abnormal motor patterns, train normal motor skills, and prevent and treat neurological sequelae such as cerebral palsy and mental retardation to a greater extent 4. Language and social skills training 4. Language and social skills training: Integrate the training activities into the child’s daily life, and ask the parents or other guardians of the child to talk, sing, tell stories and play games with the child as much as possible, and encourage the child to communicate with others. Provide the child with toys that are large, bright or shiny, make sounds, are easy to touch or smell, and are intellectually stimulating to increase the child’s interest in entertainment and provide good stimulation. For those who have language, swallowing and chewing coordination disorders, the language rehabilitation teacher actively corrects them. 5.Parent training: Parents’ association meeting is held every year to teach them the content and significance of the six principles of “early, comprehensive and persistent” for pediatric neurological rehabilitation; the content of normal and abnormal development of children, so that they can detect abnormal development in time. For those who have neurological sequelae, the parents are taught specific family rehabilitation training methods and problems that should be paid attention to in the daily life of the child, and the cooperation of the parents is obtained to provide uninterrupted treatment for the child. 6. Early childhood education: It is implemented by guiding parents, and the specific practice is similar to that of early education for normal children. The content is mainly parenting stimulation and play, so that children feel the colorful external environment, namely various colors, diverse shapes and different sounds. Hang some brightly colored or loud toys on the bed and bedroom wall, and change them from time to time to arouse the child’s interest in seeing and hearing. Give some common objects to develop the child’s mouth, eye and hand exploration skills. When feeding and caring for the child, constantly talk affectionately with the child to tease the child into happy vocalizations. Social adaptation and interaction skills can be promoted by talking and singing with the child. Develop early childhood education children’s perceptual discrimination, communication, fine motor and gross motor control through a variety of play. From 1-2 years old, children are trained to use simple words and phrases to express their wishes and needs through language training and coordination of movements, and to develop the ability to understand language. Through hands-on activities, hands-on games, painting, flipping books, and life manipulation, children develop their hands-on skills. Through storytelling, games, dance, and sports activities, we can prolong their “focused attention” time, stimulate their curiosity and self-confidence, and develop good character such as independence, perseverance, and courage. Follow-ups are conducted 4-6 weeks after each course of treatment to detect deviations in intelligence and development, such as motor function, self-care, cognitive-social/language/neurological sequelae, etc./and to determine the next course of treatment based on the monitoring results. With the improvement of material life and the development of child health care network, early intervention for newborns with HIE is starting to enter the family. Providing early intervention knowledge and guidance on intervention methods to the child’s family, regular monitoring, and targeted early and sustained intervention can significantly reduce the emergence of disabling sequelae.