Glucocorticoids are one of the most commonly prescribed drugs by dermatologists, and their topical application (external application to the skin, lesions or intra-articular injections, etc.) occupies a very important position in the treatment of skin diseases, especially chronic inflammatory skin diseases. Liang Bo of the Department of Dermatology and Venereology, The First Affiliated Hospital of Anhui Medical University, China: weak: hydrocortisone, hydrocortisone acetate, methylprednisolone acetate; moderate: acetone-deprenylone (tretinoin), hydrocortisone butyrate, prednisone, dexamethasone acetate, fludrocortisone. Potent:betamethasone valerate, mometasone furoate, betamethasone dipropionate, fludrocortisone; Super potent:clobetasol propionate, halometasone, diflucan diacetate, betamethasone valerate. Long-term use of glucocorticosteroids may cause skin atrophy, facial erythema, capillary dilation and many other side effects. It is important to understand the grading of glucocorticosteroids in order to better use this double-edged sword and to avoid and reduce the occurrence of side effects to a greater extent.