Male infertility is a common male disease, according to statistics, one out of every eight couples of childbearing age suffers from fertility difficulties, and this number is on the rise. Infertility plagues many couples of childbearing age, causing emotional crises for couples and seriously affecting the stability of families and social harmony. The limitations of human understanding of their own reproductive physiology and pathology have added to the confusion about infertility, coupled with the many false and untrue propaganda of infertility in society and the wantonly exaggerated efficacy of some charlatan doctors on patients, adding to the misery of the majority of patients. Therefore, to further strengthen the basic and clinical research on infertility, and to provide correct guidance to patients who visit the clinic for infertility, has become an urgent task to be strengthened. It is generally believed that if a couple has a normal sexual life after marriage, without using any contraceptive measures, and fails to conceive normally for more than one year, it is called infertility, of which the male and female factors account for about 50% each. Failure to conceive due to male factor is called male infertility, and more than half of the couples will seek medical help. But due to the lack of medical knowledge about infertility, there are more misconceptions about the diagnosis and treatment of infertility, so here is a preliminary introduction to help the majority of patients with infertility. The first, a beautiful and harmonious sex life is an important guarantee of a good outcome for infertility patients. There are numerous causes of infertility, of which, sexual disharmony is an important cause of infertility. According to statistics, the proportion of sexual disharmony among infertility patients is much higher than the general population, and penile erectile dysfunction, ejaculation disorder, and low libido have a serious impact on normal conception. It is very important to actively correct various sexual dysfunctions and promote a harmonious and satisfying sexual life for couples to improve the efficacy of infertility treatment, especially to improve the success rate of natural conception. Second, although the detailed examination of infertility patients can find the cause of infertility, but there are still nearly two-thirds of patients can not find a clear cause, clinically known as idiopathic infertility. Although there is no cause, empirical drug therapy can be used for idiopathic infertility. Empirical drug therapy can improve semen quality and even conception in about 70-80% of patients, but the efficacy is unlikely to reach 100%. Third, although some better results have been achieved with drug therapy, it is usually not possible to cure the patient. The goal of drug treatment is to achieve temporary improvement in semen quality to enable the wife to conceive. After stopping the medication, the quality of semen in most patients will return to its pre-treatment state. Therefore, during the medication period, both spouses should insist on having a normal sexual life. Many patients are often unable to adhere to the medication, or drug treatment intermittent, which will affect the effectiveness of the drug. Fourth, the types of drugs given in general infertility treatment are beneficial to fertility and do not cause significant adverse effects on fertility. Therefore, it is possible to conceive normally while taking medication. There are often many patients who are afraid to have intercourse during the daily treatment, and even some couples who are worried about the adverse effects of drugs on the fetus after conception during the medication and use termination of pregnancy, which are caused by the lack of understanding of infertility treatment. Fifth, the general generation of sperm generation is nearly three months, so the duration of drug treatment is usually 2-3 months a course of treatment. Many patients are treated for one month or even one or two weeks to request a review of the efficacy of the treatment, and the efficacy of the treatment has not yet been fully reflected, not only to increase the patient’s treatment time and examination costs, but more importantly, it will cause a blow to the patient’s confidence and doubt the efficacy of the treatment. Sixth, due to the limitations of modern medical understanding of infertility, the lack of specific and effective treatment, so that the efficacy of any treatment can not reach 100%. After regular treatment some patients still can not achieve the improvement of semen quality, to achieve natural conception, at this time, can not just adhere to drug treatment, can use artificial assisted reproduction methods to achieve pregnancy. However, due to the relatively high cost of assisted reproduction, there is a certain success rate (for example, the success rate of IVF is usually only 30%-40%), and any method of assisted reproduction without formal treatment is undesirable. Finally, it is important to emphasize that medication for infertility is only part of the overall treatment, and the patient’s own factors are also very important. During the treatment period, it is very important to quit smoking and drinking, eat less spicy and stimulating food, eat a balanced diet, get up and down, get enough sleep, and exercise properly (especially for some overly obese patients).