Epidemiological survey shows that the incidence rate of liver cancer in China is 26.23/100,000 for men and 11.09/100,000 for women. In recent years, the incidence of liver cancer has increased, and the trend is younger, with men over 35 years old infected with hepatitis virus becoming the “main force” of liver cancer patients. According to clinical statistics, only less than 20% of liver cancer patients can be treated surgically after diagnosis. For liver cancer patients who cannot be surgically removed, interventional therapy has become an effective supplement to surgical treatment for liver cancer. The emergence of new materials, imaging technologies, biotechnologies and new concepts has made it possible to achieve radical and minimally invasive treatment for some liver cancer cases. The incidence of liver cancer in China ranks third in malignant tumors. Among liver cancer patients worldwide, 45% are in China. Primary liver cancer is one of the most common and difficult to treat malignant tumors in China, and its etiology is mainly related to the development and evolution of cirrhosis after hepatitis and alcohol abuse and chemical injury. At present, the preferred treatment for liver cancer is still surgical resection, however, most patients are already in the middle and late stages when they are found, and only less than 20% of liver cancer patients are suitable for surgical resection. Meanwhile, the long-term efficacy of surgical treatment is poor due to the influence of intraoperative blood transfusion and residual lesions. Non-surgical treatment is safer and more effective. It is a recognized viewpoint and the direction of joint efforts of the medical profession to apply multiple methods for the comprehensive treatment of liver cancer that cannot be surgically resected. Microwave intervention, radiofrequency intervention and argon helium knife intervention are less traumatic, less complications, less painful to patients, no toxic side effects, etc. Compared with traditional heat therapy and radiotherapy, they can easily achieve curative effect similar to surgery because they directly destroy the tumor. The survival rate of patients with liver cancer after microwave knife treatment is 82.3% in one year, 72.1% in two years, 59% in three years, and 36.8% in five years, as illustrated by a large number of reports at home and abroad.