Patient: Two months ago I was diagnosed with tuberculous pleurisy due to pleural effusion and was treated with isoniazid, rifampicin, pyrazinamide and ethambutol, which I take once a day. Now the pleural effusion has been completely absorbed, but the uric acid has been increasing since I took the medication, and now it has reached 850, while other liver function tests are normal. Dr. Li, is my treatment reasonable? Should I adjust my treatment plan? What should I do to deal with high uric acid? Xiaodan Li, Department of Respiratory Medicine, Beijing Hospital, Ministry of Health: Hello, your treatment plan is suitable for most TB patients. Currently your main problem is elevated uric acid. The drug you are using that may cause elevated uric acid is pyrazinamide. I don’t know what units of uric acid you are talking about, 850, because different units mean different levels of uric acid, so I also don’t know exactly how high 850 is and how high it is. If it is mildly elevated, I don’t think you need to change the medication for now, but if it is really high, you can consider changing the pyrazinamide out. Since elevated uric acid is an adverse reaction to the drug, it should go down on its own after stopping the drug, and no special treatment is needed for the time being, unless there are symptoms associated with it.