For a period of time, there are many cases of liver tumor patients with negative AFP and negative liver biopsy who hesitated in their determination to do treatment or not and to review after treatment, and even questioned the diagnosis of liver cancer, coupled with various diagnostic opinions, even the negative diagnostic opinions of authoritative hospitals, which made the patients relax their vigilance and did not receive enhanced imaging examination of liver tumor as required for a long time, resulting in the emergence of new intrahepatic metastases and extrahepatic metastases very It is regrettable that they only remembered the examination when they had symptoms for a long time and missed the best time for treatment. There are also many doctors, even specialists, who also have insufficient knowledge of such diseases, and when talking to patients to confess their conditions, they also tend to go along with their thinking and comfortingly do not give affirmative opinions, leading patients to think that their primary care doctors also have questionable misjudgment of their diagnosis. Patients with liver disease should be reminded to seek experienced imaging physicians (ultrasound, CT, MRI) for examination and diagnosis on time, no matter what the case is, and when there is disagreement, they should observe closely or conduct further examination such as liver aspiration biopsy or wait for its change. For patients with AFP-positive liver cancer, especially those treated, dynamic observation of AFP level is a convenient observation indicator. Often, AFP is elevated again, indicating recurrence or metastasis, which will remind patients to check and treat in time, while about 40% of people have negative AFP, which is not conducive to dynamic observation of patients’ condition. For liver cancer patients with liver puncture biopsy, a positive diagnostic result is the gold standard for liver cancer diagnosis, but due to many factors such as sampling and pathological sectioning, a negative result cannot exclude the diagnosis of liver cancer, and sometimes the need for multiple multi-point puncture will increase the positive rate of diagnosis, so even if 1-2 puncture biopsies are negative, dynamic monitoring and repeated examination are still needed to prevent false negatives and delay the best time for treatment.