Immunoglobulin test is mainly used for autoimmune diseases, infectious diseases, allergic diseases, etc., which can provide certain clinical reference value for the above diseases. Immunoglobulin is mainly divided into four types: IgG, IgM, IgA and IgE. Different types of immunoglobulin are involved in different immune reactions of the human body, among which abnormalities of IgG, IgM and IgA are mainly seen in autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis, as well as infectious diseases such as viral infections and bacterial infections. IgE abnormalities are mainly seen in bronchial asthma, atopic dermatitis, urticaria and other allergic diseases, and parasitic infections and other infectious diseases. Patients with abnormal immunoglobulin also need to further improve the blood routine, C-reactive protein, blood sedimentation, anti-autoantibodies and other related auxiliary tests to clarify the diagnosis. It is recommended that patients go to the rheumatology and immunology department of regular hospitals, the infection department and other related departments for consultation, and follow the doctor’s instructions to complete the relevant examinations and standardized diagnosis and treatment.