Varicocele rarely occurs in men before puberty, and its incidence increases with age after puberty. The increase in testicular volume and the increased blood supply to the testes are associated with it. Some data report that the incidence of varicocele is 20-35% in men with infertility, and as high as 39% in some cases. Ninety-eight percent of varicocele occurs on the left side, due to anatomical reasons. In semen with varicocele, there may be oligospermia, decreased sperm motility, immature sperm cell morphology and increased malformed spermatozoa. In varicocele the venous blood return is slow, the veins are thickened and tortuous and prolonged, and the local temperature of the testes is increased, which affects the spermatogenesis. The scrotal temperature of patients with varicose veins is 0.6°C higher than the normal scrotal temperature. Due to obstruction of seminal vein reflux, stagnation leads to accumulation of CO2 in the body, which in turn leads to hypoxia and increased carbonic acid in the body, resulting in lactic acid accumulation, interfering with the normal metabolism of the testes and affecting spermatogenesis. Blood stasis, so that the local blood circulation of the testes within the catecholamine pus elevated, resulting in and serotonin elevated, can cause vasoconstriction, so that the testes immature sperm prematurely shed, into a spermatozoa. Severe varicose veins can cause the prostaglandins secreted by the adrenal glands to flow back into the testicular blood circulation, reducing testicular blood flow and causing the epididymal duct to contract, which is not conducive to the maturation of sperm in the epididymal duct and even has an inhibitory effect on the testes. The secretion dysfunction of the testis itself affects the biosynthesis of testosterone, which also interferes with spermatogenesis. Varicocele on the left side not only affects the normal function of the left testis, but also can involve the right spermatic vein through the traffic anastomosis of the left and right testicular plexus, and more importantly, the toxic substances in the venous blood on the left side can reach the right testis, so that the spermatogenic function of both testes can be affected. This is why patients with varicoceles have a great relationship with fertility, although mild varicoceles may have no significant effect. In infertile men, if they have varicocele, the treatment should be preceded by laparoscopic high ligation of the spermatic vein, followed by medication, in order to receive good results.