Whether liver cancer should be liver transplantation has always been a question faced by patients and families, especially after hearing the news of many liver cancer patients who died of recurrence after liver transplantation, it increases the doubts. So, should liver transplantation be chosen or not? Overall, the efficacy of choosing liver transplantation for various liver cancers is due to all other treatments. First of all, for small liver cancer, the risk of recurrence after liver transplantation is very small, and the patient can survive for a long time after transplantation; even for large liver cancer, without transplantation, there will be no effective treatment, and most of the survival time is 3-6 months, while transplantation can prolong the survival time and improve the quality of life. The death of some celebrities after liver transplantation as reported by the media is mainly due to the fact that these patients are large liver cancer patients and the time for transplantation is too late, so it is understandable that the total recurrence rate after surgery is high. At present, it is believed that the recurrence of liver cancer after liver transplantation is mainly related to the following factors: tumor diameter, tumor number, degree of pathological differentiation, presence or absence of vascular infiltration, and presence or absence of lymphocytic reaction. Those with large, multiple tumors, low degree of cell differentiation, and with vascular infiltration without lymphocytic reaction have high malignancy and relatively high chance of postoperative recurrence. Since only the number and size of tumors and the presence or absence of large-vessel cancer emboli can be determined preoperatively, it is now mostly recommended to judge the risk of postoperative recurrence and prognosis based on the diameter and number of tumors and the presence or absence of large-vessel cancer emboli. For patients with single tumor less than 5cm in diameter, multiple tumors not more than 3 and maximum diameter not more than 3cm have low chance of recurrence after surgery and are good indications for liver transplantation; for those who exceed this standard, the survival time is about half a year without transplantation, so transplantation can prolong the survival time and improve the quality of life, so transplantation can be considered if the donor liver is sufficient and the economy allows. Patients with liver cancer should undergo chemotherapy during and after surgery, and the application of immunosuppressants should be individualized to minimize the dosage under the premise of avoiding rejection, which can avoid and delay tumor recurrence to the greatest extent.