Mycoplasma is the smallest microorganism between bacteria and viruses that can be successfully cultured in the absence of living cells. It is able to pass through bacterial filters and has no cell wall structure, thus showing morphological polymorphism. Mycoplasma is widely distributed in nature and 8 species have been isolated so far, involving humans, animals, plants, insects, etc. Fifteen species of mycoplasma have been isolated from humans, and the main ones that cause disease in humans are Mycoplasma pneumoniae, Mycoplasma humanum (Mh), Mycoplasma genitalium and Ureaplasma urealyticum (UU). Mh and UU are the most common mycoplasmas detected in the human genitourinary tract. Mycoplasma can normally reside in the mucosa of the human cavity and can develop into a pathogen when the body is immunocompromised or the mucosa is damaged. Ureaplasma urealyticum is a common mycoplasma of the genitourinary tract. The parasitism rate in the genitourinary tract of men and women fluctuates around 20%. Even normal people can be detected with Ureaplasma urealyticum. There are 14 serotypes of Ureaplasma urealyticum, and specific serotypes are pathogenic. Whether Mycoplasma alone causes inflammation of the genital tract is controversial. Mycoplasma is clinically thought to be associated with some infertility and miscarriage. Testing is generally performed clinically for recurrent genitourinary infections, infertility, etc. Tests are available for qualitative and quantitative testing (including drug sensitivity testing). Serum subtype testing is not currently performed clinically. Quantitative testing is explained here. Mycoplasma is relatively pathogenic, and its pathogenicity is related to its number. It is only pathogenic when its number is greater than 104 units. If it is less than 104 units, it can be considered as a normal host. Therefore, the mycoplasma test mentioned earlier is still positive, there can be two situations: it does persist and the quantitative determination is greater than 104 units, with pathogenicity; although it is present (it may already be a different serological subtype), the quantitative determination is less than 104 units. There are three major classes of antibiotics for the treatment of mycoplasma: tetracyclines, macrolides, and quinolones. Of these drugs, sensitivity and resistance reported by domestic and international investigators are not consistent. In other words there is no specific drug for the treatment of mycoplasma. Since the parasitism rate of mycoplasma fluctuates at 20% and some of these people are able to have children normally, why is it not advisable to get pregnant if you are positive for mycoplasma? Personally, I think it is advisable to choose a quantitative test for mycoplasma, as long as the number is greater than 104 units, only when the drug sensitivity test to select drugs for a systematic treatment. If the number is less than 104 units, the test will be effective. If it is still greater than 104 units, it is best to observe. When the body’s immunity improves, then you can also be treated with Chinese herbal medicine, which will naturally weaken or clear the mycoplasma. Repeated use of drugs, one is the side effects, the second is the immunity is affected, more detrimental to the recovery. There is a saying in Chinese medicine, “If the righteousness exists within, the evil cannot dry up.” It means that the body’s resistance (immunity) is strong, the disease will not invade. As for Chlamydia, it is highly pathogenic and contagious. As long as the detection should be systemic treatment. The efficacy of treatment is certain.