Amniocentesis is recommended for high risk of Down’s syndrome. High risk of Down’s syndrome indicates a high likelihood of trisomy 21, and amniocentesis is recommended as an option for clarity. Down screening is a test done by pregnant women in the middle of pregnancy, mainly to check whether the fetus has chromosomal abnormalities. It is a blood test for hormones and combined with the pregnancy time of the pregnant woman to project the risk of chromosomal disorders in the fetus. If the result of the Down’s syndrome test is high risk, it means that the fetus has a higher probability of having trisomy 21, then it is recommended that amniocentesis be done to determine whether the fetus has trisomy 21, and if so, it is recommended that labor be induced. Non-invasive DNA testing is a screening test and does not have the ability to confirm a diagnosis. The Down’s syndrome test is a screening test and may be inaccurate. It is not diagnostic on the basis of this test alone and further prenatal diagnosis is recommended.