Glucocorticoids are a double-edged sword with powerful anti-inflammatory and immunosuppressive effects and are the most commonly used drugs in the treatment of autoimmune diseases. It is this powerful immunosuppressive effect that can lead to side effects while altering the pathological process. These include, among others, full-moon face formation. “Love of beauty is in everyone”, especially in women with kidney disease, and lupus nephritis, which happens to involve women, who are affected by the appearance of the full-moon face that appears and are full of worries. How to reduce the appearance of full-moon face? Glucocorticoids affect the metabolism of sugar, fat and protein, promote protein decomposition into sugar, reduce the utilization of glucose, increase blood sugar, liver glycogen and muscle glycogen, and promote the deposition of fat. Long-term application can cause “Cushing’s syndrome”, which is characterized by obesity in the face, neck and trunk, and a special body shape in the cheeks and shoulders due to fat accumulation, such as “full moon face” and “buffalo back”. The “full moon face” and “buffalo back”. In addition, water and sodium retention may also be involved in the mechanism of full-moon face formation. II. Measures and suggestions 1. Choose the best hormone type: Generally speaking, dexamethasone is easy to induce full-moon face due to its strong action strength and water-sodium retention, and its long-term use is not recommended. Medrol is slightly more likely to induce full-moon face than prednisone, but it has some other advantages such as strong immunosuppressive effect and easy to reach the lesion site, etc. Patients can use it at their discretion. 2. Minimize the hormone dosage: full moon face will generally gradually fade on its own after hormone dosage reduction or discontinuation, and can return to normal after several months or a longer period of time. In order to reduce the hormone dosage, some immunosuppressants can be used. 3, with Chinese medicine: Chinese medicine identifies the symptoms of Yin deficiency and Yang hyperactivity, clinical with internal consumption of Zhi Bai Di Huang Wan, Yu Niu Decoction, Consistent Decoction, etc., can enhance kidney function, improve human immunity and eliminate the side effects of hormone drugs. From clinical observations and pharmacological studies, these Yin nourishing and heat clearing herbs can counteract the decrease in plasma cortisol concentration after continuous administration of hormones, and prevent atrophy of the adrenal cortex, which has the effect of counteracting the inhibitory effect of hormones on the pituitary-adrenal system. It also has bidirectional regulation of blood sugar, blood pressure and blood lipids and diuretic effect to avoid water and sodium retention. Therefore, the combination of Liu Wei Di Huang Wan and hormone drugs can effectively eliminate the side effects of hormones and prevent the occurrence of swelling, obesity, hypertension and hyperlipidemia. 4, pay attention to diet and exercise: should be low salt, low fat, low sugar, high protein diet and vitamin-rich diet, eat more food to reduce swelling and dampness, such as winter melon, corn, mung bean sprouts, etc.. More outdoor exercise, appropriate exercise, you can move your face more, chew a chewing gum, it is recommended to wash your face with cold water to help recover and accelerate the decomposition of fat.