Blistering of the lips in children is mainly considered to be caused by infection with the herpes simplex virus. Mostly seen in infants and young children, the onset of the disease is usually urgent, the oral mucosa or perioral area appear clusters of small blisters, break down to form shallow ulcers, forming a crust on the skin around the mouth, generally have a self-limiting, systemic reaction is light. The diagnosis is clear that the herpes simplex virus infection is caused, the main treatment methods are: 1, systemic antiviral treatment: acyclovir and ribavirin, generally oral can be taken. 2, local medication: (1) mouthwash: 0.1%-0.2% chlorhexidine gluconate (chlorhexidine) solution, compound boric acid solution (Dobelle mouthwash) gargle, can play the role of sterilization and disinfection. (2) Ointment application: 3% acyclovir ointment is applied locally; (3) Dispersion: tin type dispersion, watermelon cream powder are available; (4) Warm saline: 0.1%-0.2% chlorhexidine solution or 0.01% zinc sulfate solution is applied wet. 3. Physical therapy: helium-neon laser treatment. 4, for more serious conditions and feeding difficulties: intravenous fluids, vitamin supplements, etc., drugs should be used under the guidance of a doctor. Meanwhile, children should usually pay attention to oral hygiene. After each meal, they should rinse their mouth in time to keep it clean. Children should be taught how to brush their teeth properly to remove food residues and reduce oral infections.