High suprahepatic hemoglobin indicates abnormal liver function, which can affect the health of the patient. The metabolism of bilirubin in the body requires the participation of the liver, which is the site of conversion of direct and indirect bilirubin, so a decrease in liver function will result in a subsequent decrease in the ability to convert bilirubin, which will raise bilirubin in the blood.
At the same time, when stones, inflammation, or tumors develop inside or outside the liver, the patient’s liver is unable to function properly, which can lead to obstruction of bile excretion and backflow into the bloodstream, resulting in elevated bilirubin. When direct bilirubin is elevated, biliary obstruction can occur and diseases such as hepatitis, cirrhosis, and primary biliary cirrhosis can occur.
Also blood disorders such as leukemia, severe anemia, malaria, and hemolytic anemia can lead to massive destruction of red blood cells and a large increase in indirect bilirubin in which the liver cannot convert it all, resulting in an increase in indirect bilirubin in the blood.
Biliary tract diseases, such as gallstones, bile duct tumors, and cancer of the pancreatic head, can lead to elevated bilirubin, which enters the intestine from the bile duct.