With the liberalization of the two-child policy, many post-70s women began to struggle with the issue of having a second child or not, but in addition to the permission of the policy and the adoption of the family meeting, this part of the women also have to think about, the physical condition. Women’s natural fertility begins to decline after the age of 3 5, which is the end of the 70s, and although many women are still having children after the age of 40, usually, most women have completely lost their fertility several years before menopause. Although assisted reproductive technology (ART) can solve the fertility-related problems of many infertile couples, it cannot make up for all families. Women who undergo IVF are too old and have declining ovarian reserve function, which is the main reason for IVF failure. 1. Women over 35 years of age need to be aware of the fact that their chances of conception are significantly lower than those of younger age groups, and that the fertility of women over 40 years of age is significantly reduced 2. For women over 40 years of age, doctors are obliged to inform older mothers of the risks of pregnancy, including the relatively high risk of miscarriage, and the increased risk of pregnancy complications. 3. For women with combined diabetes and hypertension, a joint consultation with an obstetrician and an internist is required before pregnancy to assess the risks of pregnancy. 4. If conditions permit, both partners should undergo a comprehensive medical examination including preconception tests. Obstetrics and gynecology should include: gynecologic examination, cervical cytology screening (currently mainly TCT), ultrasound of the uterus and both adnexa. If financial conditions allow, screening for both high-risk HPV virus and TORCH testing is recommended. 5. Take one 0.4mg tablet of folic acid daily starting three months before the planned pregnancy until three months after successful conception. If the pregnancy is unplanned and there is no folic acid supplementation in advance, do not over panic and just start taking it in time. 6. For women with regular menstruation, maintaining a regular sex life (2-3 times/week) since the last clean period can help increase the chance of conception. The 6 days before ovulation is medically defined as the “conception window”, and if you can maintain a frequent sex life within these 6 days (1-2 days), you will have the best chance of conception. 7. Once you have successfully conceived, you should have prenatal checkups as early as possible. Pregnancies in women over 35 years old are medically known as high-risk pregnancies, with an increased risk of delivering a fetus with chromosomal abnormalities/malformations. chromosomal abnormalities in the fetus). 8, healthy diet, exercise and regular routine need not be stressed, whether or not to have children, women will benefit for life if they can always do so. For example, avoid smoking, excessive alcohol consumption, excessive coffee, drug use, exposure to toxins or harmful chemicals. 9, about the mode of delivery: advanced age is not an absolute indication for cesarean delivery, it is recommended to adopt a good lifestyle of healthy diet and regular exercise before pregnancy, and insist on exercise during pregnancy to control weight and avoid oversized fetus, if there is no contraindication for vaginal delivery, advanced maternal age can also be delivered smoothly. 10. If the first child was delivered by cesarean section, it is important to assess the thickness of the original uterine scar before pregnancy, such as the distance between the pregnancy capsule and the scar by ultrasound once the pregnancy is about 50-60 days.