There are five major classes of first-line recommended antihypertensive drugs, and some of the most commonly used class of calcium antagonists can cause ankle edema. This side effect also varies from person to person, only a small percentage of people will experience ankle edema when using this drug. And with the increasing level and variety of preparations available, many people no longer experience ankle edema. All drugs with the name of diphenhydramine are calcium antagonists, such as nifedipine, amlodipine, felodipine, etc., which are generally used in patients with hypertension or angina pectoris. If you find ankle edema, it does not matter if you can change the dosage form, such as switching to a new generation of modern calcium antagonists, long-acting agents will be much better. The problem can be solved by switching to other types of antihypertensive drugs, or with antihypertensive drugs containing diuretics.