Let’s start with how gout is caused. Gout is actually a recurrent inflammatory disease caused by increased purine biosynthesis, excessive uric acid production or poor uric acid excretion resulting in elevated uric acid in the blood and deposition of urate crystals in synovial membranes, bursae, cartilage and other tissues. The disease is characterized by the presence of bifocal monohydrate urate crystals in joint fluid and gout stones. The clinical features are: hyperuricemia and characteristic acute arthritis due to urate crystals and deposition, gout stones, interstitial nephritis, and in severe cases, joint deformity and dysfunction, often accompanied by uric acid urinary tract stones. It is mostly seen in middle-aged and elderly men with obesity and postmenopausal women. Its prevalence is gradually increasing with economic development and lifestyle changes. Hyperuricemia cannot be called gout if there are no symptoms such as acute arthritis. It can be called gout only when symptoms are present. How purines exist; mainly in the form of purine nucleotides, they play a very important role in energy supply, regulation of metabolism and the composition of coenzymes. Purines (including adenine C and guanine G) are the material basis of nucleotides, while nucleic acids (i.e. DNA and RNA) are one of the most basic and important substances of life, and nucleic acids are biological macromolecular compounds formed by the polymerization of many nucleotides. The relationship between them is that purine is the product of oxidative decomposition of nucleic acid, while uric acid is the product of purine metabolism (2,6,8–trioxopurine). Therefore it is not purine and uric acid that cause gout, it is precisely the oxidative breakdown of nucleic acid out – purine – oxidation to (2,6,8 – trioxypurine) – i.e. the metabolic disorder of substances such as uric acid that is the pathological essence of gout. Causes of uric acid; oxidative decomposition of nucleic acid accounts for 80% of endogenous purines and exogenous purines such as food accounts for 20% of total purines. The body fails to metabolize purines into excretion products that can be excreted in the urine from the kidneys during the metabolic process by consuming foods that contain too much purine. If the blood is saturated with uric acid, these substances eventually form crystals and accumulate in the soft tissues. If there is a trigger for the release of uric acid crystals deposited in soft tissues such as joint membranes or tendons, then the body’s immune system may become sensitized and inflammation may result. If the uric acid concentration in the blood remains above this saturation point for a long period of time, it is known as “hyperuricemia”. Gout can be triggered by diet, weather changes such as sudden changes in temperature and pressure, and trauma. Alcohol consumption can easily trigger gout because when alcohol is metabolized in liver tissues, a large amount of water is blown away, which strengthens the blood concentration and accelerates the formation of crystals of uric acid in soft tissues, causing the body’s immune system to overreact (sensitive) and causing inflammation. For example, Kublai, the founder of the Yuan Dynasty, suffered from gout in his later years due to excessive drinking. Some foods are metabolized and some of their derivatives can trigger the redissolution of uric acid crystals that have accumulated in the soft tissues, which can trigger and aggravate arthritis. Compared to women, men are more likely to suffer from gout Why? Because gout disease can occur at any age. However, it is most common in middle-aged men over 40 years old. According to the latest statistics, the incidence ratio of men to women is 20:1, and the incidence is higher in brainy, fat people. The reason why gout prefers men is that estrogen in women promotes uric acid excretion and has the effect of inhibiting arthritis attacks. Men like to drink alcohol, go to banquets, and eat food rich in purines and proteins, which increases uric acid in the body and reduces its excretion. Some doctors statistics, feast constantly, the incidence of 30%, often eat hot pot incidence also more. This is because the raw materials of hot pot are mainly animal offal, shrimp, shellfish, seafood, and then drink beer, naturally adding oil to the fire. Investigation proves: shabu shabu a hot pot than a meal purine intake 10 times higher, or even dozens of times. A bottle of beer can double the uric acid. Hypertensive patients are 10 times more likely to suffer from gout. The key to gout patients is to control their own diet, eat more alkaline foods containing low purine, such as fruits and vegetables, and less acidic foods such as meat and fish, so that the diet is light, low fat and low sugar, and drink more water to facilitate the excretion of uric acid in the body. Caution gout patients: men should not drink alcohol, meat and fish do not overdo it. Once diagnosed with gout disease, meat, fish and seafood are among the restricted foods. Spicy, stimulating food is also not suitable to eat more, but also determined to give up alcohol. But who would have thought that this seemingly bone and joint disease is actually closely related to obesity. More than two decades ago, researchers analyzed data from 4,000 obese people and concluded that there was a correlation between gout and obesity. Half of the participants underwent weight reduction-related procedures such as gastric bypass and gastric reduction surgery (sleeve gastric surgery), while the other half underwent non-surgical treatment. The researchers found that participants who underwent bariatric surgery had a 40% lower risk of developing gout compared to those who did not undergo bariatric surgery. Weight loss surgery has a role in preventing gout due to severe obesity.