The progression of chronic hepatitis B progression: Stage 1, asymptomatic surface antigen positive pick-up carrier status. Stage 2, chronic mild hepatitis. Stage 3, chronic moderate and severe hepatitis. Stage IV, chronic severe. Stage V, cirrhosis. Stage 6, liver cancer. These five stages from chronic hepatitis to liver cancer are the natural progression of chronic hepatitis B. The majority of patients can be stabilized in the first stage for a long time, and only a few chronic hepatitis B patients will develop to the fifth and sixth stages, and the number of patients in these six stages shows a pyramidal distribution. 1. Has the disease developed from asymptomatic surface antigen positive carriers to chronic mild hepatitis? The vast majority (50%-80%) of hepatitis B patients are asymptomatic surface antigen positive carriers and can live, study and work normally. If they have normal liver function, they can continue to work; if they are not normal, have symptoms such as weakness, discomfort in liver area, loss of appetite, yellow urine, etc., and laboratory tests reveal mild abnormality of glutathione aminotransferase (ALT), they can be considered to have developed from virus carrier status to mild chronic hepatitis, and should be treated with medication under the guidance of regular doctors. 2.Has mild chronic hepatitis B developed into moderate or severe chronic hepatitis B? The symptoms of mild chronic hepatitis B are generally not obvious and the liver function is mildly abnormal, if the symptoms are getting worse, the signs are becoming more obvious and the liver function is seriously abnormal, it means that the chronic hepatitis has entered the moderate or severe stage, the symptoms can be seen as obvious digestive symptoms (loss of appetite, nausea, vomiting, loose stools, abdominal distension, etc.), the signs can be seen as yellowish or dull face, there are liver palms (the palm of the hand can be seen as dotted or flaky red depressed blood (shape), spider nevus (skin surface appears like small spider-like capillary thickening changes), from the laboratory indicators, transaminases significantly elevated, serum bilirubin (BIL) reached 40 ~ 170 mmol / liter, prothrombin activity (PA) 64% or less, globular bile white (GLO) significantly elevated, at this time, reflects the characteristics of chronic activity, easy to chronic heavy or cirrhosis development. 3.Has it developed into chronic heavy hepatitis? Chronic heavy hepatitis marks the liver has occurred a large or sub-massive necrosis, critical condition, can be accompanied by a variety of complications, manifested mainly as severe gastrointestinal symptoms, severe weakness and liver coma, ascites, gastrointestinal bleeding and other complications, from the laboratory indicators, serum bilirubin more than 170 mmol / l, prothrombin activity decreased to less than 40%, this type of serious illness, mortality is extremely high, must Early diagnosis is necessary to fight for rescue time. 4. Has chronic hepatitis developed into cirrhosis? Cirrhosis mostly develops from chronic active (moderate or severe) hepatitis, while a few develop from asymptomatic surface antigen-positive carriers or mild chronic hepatitis. The main findings are confirmed by laboratory tests and imaging tests. From the laboratory tests, albumin is reduced, globular bile is elevated (r globular bile reaches more than 29%), prothrombin activity is often below 65%, ultrasound and other imaging tests indicate a shrinking liver, nodule formation, widening of portal veins, etc. Gastrointestinal imaging shows varices in the esophagus and fundus. The middle and late stages of this type can often be accompanied by complications such as ascites and gastrointestinal bleeding. 5. Has chronic hepatitis developed into hepatocellular carcinoma? Reliable diagnosis comes from imaging examinations, such as CT, MRI, ultrasound, etc. Patients with chronic hepatitis whose fetoprotein is consistently greater than 400ng/ml should especially pay attention to timely imaging examinations for early diagnosis and early treatment. In general, middle and late stage hepatocellular carcinoma have obvious symptoms and signs, such as pain in the liver area, obvious wasting, enlarged liver, etc. Especially in patients with cirrhosis, when these conditions occur, it is necessary to pay attention to the possibility of hepatocellular carcinoma, and timely imaging examination is very necessary, as the early and late detection of hepatocellular carcinoma directly affects the therapeutic effect, and the earlier the detection, the better the therapeutic effect.