Colchicine is one of the most commonly used drugs in clinical practice for the treatment of gout. Under the guidance of a clinician, it can control local pain, swelling and inflammation in joints when taken correctly. Therefore, it is very effective in the treatment of gout if taken correctly. Colchicine is an alkaloid that reduces the deposition of uric acid crystals by decreasing the activity of leukocytes and phagocytosis and reducing lactic acid formation, thus reducing the inflammatory response and thus achieving pain relief. Colchicine reduces the activity, adhesion and chemotaxis of neutrophils and inhibits the travel of granulocytes to inflammatory areas, thus exerting an anti-inflammatory effect. Colchicine is usually effective 12-24 hours after oral administration to gout patients, and most of the patients’ pain is significantly reduced or even disappears within 24-48 hours of taking the drug. Therefore it is very effective in treating acute attacks of gouty arthritis, as well as in preventing recurrent, acute attacks of gouty arthritis. Although colchicine is very effective in relieving gout pain, its side effects are also relatively large, especially if the dosage is not controlled or if it is taken frequently, a series of side effects such as vomiting, diarrhea, abdominal pain, gastrointestinal reactions, damage to the kidneys, etc. must be taken strictly in accordance with medical advice.