Treatment of scleroderma includes general treatment, medication and other treatments. 1. General treatment: quit smoking, keep warm, avoid emotional excitement, active skin care and pay attention to the patient’s condition education, give positive psychological support and encouragement. 2. Drug therapy: the current drug therapy for scleroderma mainly includes anti-inflammatory and immunomodulatory therapy, treatment for vascular lesions and anti-fibrosis therapy. (1) Anti-inflammatory and immunomodulatory treatment: non-steroidal anti-inflammatory drugs (such as diclofenac, etc.), glucocorticoids (such as prednisone, etc.). Immunosuppressants (e.g. cyclophosphamide, methotrexate, mycophenolate mofetil, azathioprine, cyclosporine A, etc.). (2) Treatment for vascular lesions: long-acting calcium channel blockers (e.g., nifedipine), prostacyclin analogs (e.g., travoprost, celecoxib, etc.), endothelin receptor antagonists (e.g., bosentan, aliskiren, and macitentan), and thirdly nitric oxide stimulants (e.g., the type 5 phosphodiesterase inhibitors sildenafil and tadalafil). (3) Anti-fibrotic therapy: drugs such as tacrolimus, immunoglobulin, rituximab and so on. 3. Other treatments: Lung transplantation may be an effective option for patients with severe lung involvement. When scleroderma occurs, it is recommended to go to the hospital in time and follow the doctor’s instructions to standardize the treatment, and the drugs should be used according to the doctor’s instructions, do not self-medication.