Headaches can be treated with ibuprofen extended-release capsules, which are indicated for patients with mild to moderate headaches. If primary headache disorders are considered, such as tension headache and mild migraine patients can be applied, as well as acetaminophen, indomethacin and naproxen. In case of severe migraine patients, its application of ergotamine caffeine, zolmitriptan and sumatriptan for treatment. Patients with headaches can have a variety of causes, such as intracranial organic lesions that may also cause them, and the main focus is on etiologic treatment. Common diseases include cerebrovascular diseases, including cerebral hemorrhage, cerebral infarction and cranial tumors. If the patient has severe headache, central inhibitory analgesics can also be applied, and morphine can be applied for analgesic treatment. If the headache is considered to be caused by cervical spondylosis or hypertension, the main thing is to actively treat the primary cause.