Headache is a clinical symptom caused by various physical and chemical factors that injure the central and peripheral nerves in the head, resulting in a subjective experience in the body, accompanied by unpleasant emotions. Since a person experiences it almost all his life, headache is very common in neurology clinics and accounts for a large proportion of online consultations. There are many types of headaches, both organic, such as tumors, and functional, such as migraines. Without proper diagnosis, treatment can be difficult and sometimes misleading. In order to help patients to have a clear understanding of this, here, we introduce the manifestations of different headaches through several cases. A. High cranial pressure headache The patient, female, 38 years old, was seen for 3 months mainly because of head distension and pain with vision loss, headache located in forehead and temporal top, jumping or distending pain, sometimes nausea and vomiting in the morning, and gradual vision loss. The boundary of the optic papilla was unclear, and the brain CT showed a glioma in the right posterior frontal lobe. Inflammatory headache The patient, male, 24 years old, presented with fever with headache for 3 days. He had a history of cold before the onset of the headache, and the headache was tearing-like distension with violent vomiting, accompanied by chills, neck tonicity, pallor, increased blood count, and increased CSF pressure at lumbar puncture with a rice-tan color. The patient, female, 38 years old, had a history of recurrent headache for nearly 20 years, and each attack was preceded by five-color vision or blackness in front of the eyes, followed by a headache attack. The headache is mainly distending or throbbing pain, lasting 1 to 2 days, with vomiting in severe cases, which can be relieved by rest. There was no effect on visual acuity. CT and EEG are normal. IV. Neuropathic headache (including herpetic) The patient, an elderly male with a history of diabetes mellitus for 10 years, developed posterior occipital whiplash-like pain in the last 3 months, which can be triggered by head and facial movements such as drinking, swallowing, opening the mouth and turning the neck, and can radiate upward. The pain can sometimes be awakened during sleep, and general painkillers are effective but short-lasting. V. Depressive anxiety headache The patient, an elderly female, had headache and dizziness with fear and tension for 1 year. Because her husband was suffering from an advanced tumor, she was unable to rest, insomnia and emotional instability because of long-term care; the headache was a vague pain in the whole head with deeper parts, often with discomfort in other parts of the body. The symptoms varied in severity with mood fluctuations, objective neurological signs (-), and no abnormalities in relevant examinations. The patient, a 54-year-old female, recently presented with persistent orbital and forehead distension and pain, accompanied by nausea and vomiting in severe cases, photophobia, tearing, and sometimes colorful hallucinations or blurring of vision. On examination, the conjunctiva was found to be congested, and the eyeballs were hard to the fingertips. In conclusion, the above-mentioned headaches are different in terms of etiology, attack site, attack form and accompanying symptoms, and treatment and examination are also different.