Systemic scleroderma is generally referred to as scleroderma, and the amount of life expectancy cannot be generalized; when the disease is well controlled, you can live for 10 to 20 years or more, and when the disease is poorly controlled, you may only live for 2 to 3 years or even less. Scleroderma is a connective tissue disease that is related to genetics, immunity, and infection. Patients may have skin lesions, Raynaud’s phenomenon or limb pain and other symptoms, and cooperate with the doctor to actively carry out drug treatment, drug treatment can follow the doctor’s advice to use methotrexate, cyclophosphamide and other drugs. When the disease is well controlled, the patient can live for 10 to 20 years or even longer. If the patient’s condition is not well controlled, combined with multiple organ involvement, serious complications may occur, such as interstitial fibrosis, pulmonary hypertension, renal failure, etc., which will lead to shorter life expectancy, and the patient may only be able to live for 2 to 3 years, or even shorter. Once scleroderma patients are diagnosed, they should cooperate with rheumatologists and immunologists to actively carry out treatment, and should also regularly review their bodies to understand the changes of the disease, pay attention to the changes of the skin and blood pressure in daily life, pay attention to the hygiene of the diet, and actively exercise to maintain the elasticity of the joints.