The following is a brief introduction to part of the recent coursework of Canadian professor Harry L, A, Janssen on new research advances in HBV treatment interventions: 1. Novel nucleoside analogues: belong to DNA polymerase inhibitors, including tenofovir elaprolide (phase III), AGX-1009 (phase II), Besifovir (phase III), and Lagociclovir valacate (phase II); 2. Immunomodulators: are cytokines with immunomodulatory and antiviral effects, including pegylated interferon λ (phase II), TLR-7 agonist (phase III); 3. Viral invasion inhibitors: target sodium/taurocholic acid cotransport peptide receptors to inhibit viral infection of new cells, including Myrcludex B (phase IIa), cyclosporine (basic research), and oxysterols (basic research); 4. Assembly effector molecules: inhibit HBV replication by causing destabilization of viral particles, including HAP (phase I), phenylacrylamide (basic research), isothiofluridine (phase II), and NVR-1221 (phase I); 5. HBsAg release inhibitors: inhibit HBsAg release by inhibiting HBsAg subviral particle release to enhance the recovery of immune response, including REP 9AC (phase II); 6. RNA interference/RNAi gene silencing: inhibit gene expression and neo-virionome release by RNA molecules, including ARC-520 (phase I), antisense oligonucleotide (phase II), ISIS-HBVRX (phase II), ALN-HBV (basic research) , TKM-HBV (basic research), NUC B 1000 (basic research); 7. Therapeutic vaccines: by inducing and stimulating CD4+ and CD8+ T cell responses, including Tarmogen (phase III), Transgene (phase I); 8. cccDNA degradation/silencing: by upregulated APOBEC3A and APOBEC3B causing cccDNA degradation, including interferon alpha (phase I), lymphotoxin beta receptor (phase I); 9, suppressive T lymphocytes: by blocking inhibitory signals and/or activating costimulatory signals, including PD-L1 blockers (phase IIa); The eradication of hepatitis B may require a combination of multi-targeted therapeutic measures, and after hepatitis C is completely curable, it is believed that in the near future, the eradication of hepatitis B will also be achieved The hepatitis B treatment will be achieved in the near future.