Acne, commonly known as “pimples,” can be a sign of adolescence. Usually, most people’s acne subsides naturally after puberty. However, there are some patients who do not develop acne until after puberty or even into adulthood, and others who develop it from puberty into adulthood. These two types of acne are known as late-onset acne and persistent acne, respectively. The majority of these patients are women, who often ask their doctors, “Is there something wrong with my endocrine system? . Yes, it is true that the majority of these patients are reported in the literature to have increased androgen production. The increase in androgen secretion leads to the proliferation of sebaceous glands, which increases the synthesis and secretion of sebum. At the same time, androgens cause the hair follicles to become keratinized and the pores to become clogged. Since female androgens mainly originate from the adrenal glands and ovaries, the causes of female acne after puberty lie in two areas: 1. This leads to the occurrence of acne, and most of these patients are professional women. In comparison, the second factor is common in post-pubertal acne in women. Alcohol consumption and spicy food can aggravate the symptoms of acne. Because of the adverse effects of Western medicine, these acne patients often choose Chinese herbal treatments. According to Chinese medicine, “blood is the essence, and qi is the key”, which means that “qi” and “blood” are the first factors that change when a woman’s pathological and physiological state changes. As menstruation, pregnancy, childbirth and breastfeeding repeatedly injure blood, women are in a state where Yin is often deficient and Yang is always in surplus, which is the inherent condition for the occurrence of this disease. Due to the deficiency of kidney essence, the lack of source of the flush, the deficiency of spleen and kidney yang, phlegm and dampness, and the stagnation of liver qi, which turns fire into heat, lead to the occurrence of this disease. Treatment is based on nourishing the liver and kidneys and regulating the flushes. If the occurrence and severity of acne is obviously related to the menstrual cycle, then the main treatment is to nourish Yin and clear heat, and regulate the flushing. The above concepts of Chinese medicine may be obscure and difficult to understand for the general public, but if we analyze the herbal formulas from a modern medical point of view, we will find that the herbs also target several aspects of the pathogenesis of acne, for example, snake’s tongue, deer’s tongue, tansy and orange leaf have anti-androgenic and sebaceous gland activity inhibiting effects. The sebaceous secretion of sebaceous glands can be inhibited by the Radix Scutellariae Sinensis, Radix Scutellariae Sinensis, Radix Angelicae Sinensis and Radix Angelicae Sinensis. If polycystic ovary syndrome is detected through examination, a gynecologist should be involved in the treatment. In addition, good lifestyle habits are a guarantee of healthy skin, and maintaining a relaxed mood, adequate sleep, and a reasonable dietary structure are important in preventing the recurrence of acne.