The etiology of cerebral atrophy is complex and the pathogenesis has not been fully elucidated, so there is still a lack of effective therapeutic measures for cerebral atrophy. At present, symptomatic improvement of clinical symptoms is still the main treatment method, mainly the following treatment methods: 1, drug therapy: is currently the most widely used treatment method, can be added with olanzapine, nimodipine and other drugs to improve microcirculation, promote brain metabolism to improve symptoms and delay disease progression; can also be added with cholinesterase inhibitors, such as donepezil, carboplatin, etc. to increase the concentration of acetylcholine in the brain, to improve memory and improve the patient’s cognitive function. In addition, antidepressant or anxiolytic drugs can be added to improve the patient’s anxiety, depression, apathy and other mental symptoms. 2, neurotrophic factor, stem cell therapy: neurotrophic factor has the function of promoting the repair and regeneration of damaged nerve cells, and some studies have shown that intravenous injection of neurotrophic factor can improve the symptoms of patients with cerebral atrophy. Another study shows that autologous stem cell transplantation can improve the clinical symptoms of patients with cerebral atrophy and restore their brain function to a certain extent, but this therapy is still in the research stage and has limited clinical application. 3, Chinese medicine, traditional Chinese medicine therapy: for some patients with cerebral atrophy on the basis of Chinese medicine identification, blood circulation, blood nourishment, kidney and marrow and other soup therapy can improve the patient’s symptoms to a certain extent, delaying the progress of the disease. 4, comprehensive patient management: for patients with cerebral atrophy should encourage patients to try to maintain their ability to live, participate in social activities, strengthen rehabilitation treatment and training, adhere to follow-up visits, and adjust the treatment plan in a timely manner. In summary, there is still a lack of effective treatment measures for cerebral atrophy, and the best treatment is still based on drug therapy to improve clinical symptoms and delay disease progression.