Cerebral atrophy is a disease characterized by a reduction in brain cells and a decrease in brain volume due to various causes. The life expectancy of patients with cerebral atrophy is directly related to the patient’s condition and personal status, among which, the more common middle-aged onset and slow progression of cerebral atrophy does not significantly shorten the life expectancy of patients compared to normal people. The life expectancy of patients with cerebral atrophy is related to various factors such as the cause of the disease, the age of onset, the rate of progression, the effectiveness of treatment and the patient’s own state. First of all, the causes of cerebral atrophy are complex, among which the more common causes are cerebrovascular lesions caused by hypertension and hyperlipidemia, and atrophy of brain tissue due to long-term chronic ischemia, which generally start later and develop slowly, and have no significant impact on the survival of patients. However, if the patient is suffering from brain tissue necrosis and atrophy caused by brain tumor or poisoning, the disease will progress rapidly and the patient will eventually die due to gradual loss of brain function. Second, the responsiveness of patients with cerebral atrophy to drug therapy is also related to the patient’s life expectancy. If patients have symptoms such as memory loss and unresponsiveness, the addition of brain metabolism activators and drugs to improve cognitive function can improve their symptoms, i.e., patients with better response to treatment will live longer than those with poor response to drug therapy. In addition, if patients with cerebral atrophy can try to maintain their ability to live, participate in social activities, strengthen rehabilitation treatment and training, and maintain a good diet and living habits and have a good attitude, it also has a great positive significance to prolong their life expectancy. In summary, the life expectancy of patients with cerebral atrophy cannot be generalized, but depends on various factors such as the cause of the disease, age of onset, speed of progression, treatment effect and the patient’s own state.