Cerebral atrophy can be caused by a variety of diseases, such as genetics, traumatic brain injury, sequelae of poisoning, cerebral infarction, cerebral small vessel disease, encephalitis meningitis, cerebrovascular malformation, brain tumour, epilepsy long-term seizures, excessive smoking and drinking, thyroid function lesions, cerebral arteriosclerosis, gas poisoning, alcoholism, etc. causing destruction of brain parenchyma and atrophy of nerve cells, of which the most important causative factor is caused by long-term chronic ischemia of cerebral blood vessels .
Clinically, hypertension, dyslipidemia, and cerebral small artery sclerosis are important risk factors for senile cerebral atrophy.