1.Cautions about anticoagulation therapy: After heart valve replacement, anticoagulation therapy with anticoagulant drugs is required to prevent thrombosis around the mechanical valve. Warfarin is currently the most commonly used drug. Due to the need for lifelong use. In the process of use, the following matters need to be noted: (1) Be sure to review the prothrombin time (PT) regularly to maintain it between 20-30 s. For longer PT time, the dosage of warfarin should be reduced, and for shorter PT time, the dosage of warfarin should be increased. Patients should preferably have their PT checked every 3 months after the PT has stabilized.Chen Qunqing, Department of Cardiothoracic Surgery, Zhujiang Hospital, Southern Medical University (2) When adjusting the warfarin dosage, it needs to be reviewed within 1-2 weeks, and the dosage can usually be increased or decreased by 1/2 tablet each time. (3) While taking warfarin, if you get other diseases, especially if you want to have surgery be sure to explain your situation to your doctor. (4) Try to avoid trauma or situations that tend to produce bleeding while taking warfarin. In the event of trauma, if the bleeding is only superficial, apply more pressure to stop the bleeding and keep the pressure on for a longer period of time. In case of internal bleeding including coughing up blood or vomiting blood, go to the hospital emergency room as soon as possible and inform the doctor of your condition. (5) Warfarin has a certain effect on fetal development and has a certain teratogenic rate. You should be hospitalized in advance until delivery.