Anticoagulants (warfarin): Because the prosthetic valve is not the body’s own tissue, blood tends to clot in and around the prosthetic valve, causing a blood clot. Therefore, anticoagulants are used for life after mechanical valve replacement surgery to prevent the formation of blood clots. It is important not to forget to take anticoagulants on time, as this can lead to the formation of blood clots on the valve surface and their dislodgement causing embolism in various parts of the body, and may also cause the valve to become inoperable; an overdose of anticoagulants can cause bleeding in various parts of the body. Therefore, the patient must take the medication as prescribed by the doctor and do the following: 1, should be clear about the name and dosage of the drugs they take: according to the doctor’s orders taken at the same time every day, do not arbitrarily change the variety of anticoagulants, dosage and time to take the medication. 2, after discharge from the hospital every 1 week blood test prothrombin time, 3 times in a row to reach the required value changed to 2 weeks to check once, 3 times in a row to reach the required value changed to once a month, after the prothrombin time should be tested every 1 month until 1 year after surgery, the second year can be tested once every 3 months. The prothrombin time is to indicate how long it takes for the patient’s blood to coagulate, and the result should be 1.5 to 2 times the normal value. If it is lower than 1.5 times or higher than 2.5 times, the dose of medication should be increased or decreased by 1/8 to 1/4 and tested again after 3 days until it is close to the requirement. 2. Drug factors interfering with anticoagulation therapy: phenobarbital, aspirin, dipyridamole (Pansentin), indomethacin (anti-inflammatory pain), chloramphenicol, neomycin and other drugs can enhance the anticoagulant effect, and vitamin K: and other hemostatic drugs weaken the anticoagulant effect. When the above drugs must be applied, the doctor will guide and observe their use, and make several laboratory checks to adjust the dose of anticoagulants. 3.Diseases affecting anticoagulation therapy: hepatitis, heart failure, fever, hyperthyroidism can cause an increase in the sensitivity of oral anticoagulants; poor intestinal absorption during diarrhea can weaken the effect of oral anticoagulants. 4, during anticoagulation therapy should avoid trauma to prevent hemorrhage: if there is gum bleeding, skin bleeding spots, etc. should be examined in time to adjust the dose of medication. And during the application of anticoagulant drugs should be closely observed for the occurrence of internal bleeding, such as the presence of black stool, urine, hemoptysis, dizziness, fainting or sudden chest tightness, hemiplegia or aphasia. If so, go to the hospital immediately for timely diagnosis and treatment. 5. Married women of childbearing age should use contraception: both pregnancy and childbirth are detrimental to anticoagulant patients. If you wish to have children, you should consult your doctor to obtain health care guidance. If the patient has an abnormal increase in menstrual flow during anticoagulation therapy, the dosage can be reduced by 1/8 to 1/4, but the dosage should not be stopped, and the original dosage should be resumed after the menstruation. 6, other: if the patient needs to do other surgery, should consult the cardiovascular surgeon, follow the medical advice, in 36 to 72 hours after surgery to restart anticoagulation therapy.