Single ankle pain is not necessarily gout. Gout is a crystalline arthritis formed by the deposition of uric acid crystals around the joints. At the onset of the disease, redness, swelling, heat, pain and impaired movement of a single ankle can occur, and patients can also be accompanied by systemic clinical manifestations, such as fever or even high fever. Although gout patients can have single ankle pain, other causes can also cause the same symptoms, which can also be commonly seen in the following cases: 1, sports sprain: if the recent strenuous exercise, or one side of the ankle sprain, collision and other conditions can cause single ankle pain; 2, rheumatoid arthritis: the joint swelling and pain caused by streptococcal infection, can be manifested as single ankle pain However, the pain level is lighter than that of gout and can be relieved within 2 weeks, and it is a wandering pain; 3, rheumatoid arthritis: some rheumatoid arthritis can also appear unilateral ankle swelling and pain, but the onset is often symmetrical joint, morning stiffness is more obvious, while redness, swelling, congestion symptoms are relatively light, patients can observe whether the other side of the joint appears the same symptoms; 4, spinal arthritis. Some seronegative spondyloarthritis, such as reactive arthritis, can also present with single ankle swelling and pain. There may be some triggers before the onset of the disease, such as urinary tract infection, diarrhea, etc. Compared with gout, the pain symptoms are less severe, and the congestion, redness and swelling are also less severe; 5, other: if the patient has synovitis, fracture, etc., the symptoms of single ankle pain may also appear. If patients suspect that the joint swelling and pain is caused by gout, they need to visit the rheumatology or endocrinology department to clarify the cause through joint fluid, blood uric acid and other related examinations. If diagnosed, patients need to take colchicine, glucocorticoids and other related drugs under the guidance of professional doctors to control the condition.