Sepsis is an acute systemic infection that occurs when pathogenic or conditionally pathogenic bacteria invade the bloodstream and grow and multiply in the blood, producing toxins. If the bacteria that invade the bloodstream are cleared by the body’s defenses and there are no obvious symptoms of toxemia, it is called bacteremia. Sepsis with multiple abscesses and a longer course is called sepsis. Common causes: bacteria, fungi. Common symptoms: high fever, rash, arthralgia, hepatosplenomegaly, altered mental status, shock, etc. Clinical manifestations: sepsis itself has no specific clinical manifestations. The manifestations seen in sepsis can also be seen in other acute infections, such as recurrent chills or even chills, high fever that can be flaccid or intermittent, rash with petechiae, arthralgia involving large joints, mild hepatosplenomegaly, severe Myocarditis, infectious shock, diffuse intravascular coagulation, respiratory distress syndrome, etc. The sepsis caused by various pathogenic bacteria has its different clinical characteristics. The primary lesions are often skin boils and carbuncles or wound infections, and a few are in-hospital infections with poor body resistance. The presence of petechiae on the conjunctiva is of great importance. Migratory damage can occur in about 2/3 of patients, most commonly multiple pulmonary infiltrates, abscesses and pleurisy, followed by suppurative meningitis, renal abscesses, hepatic abscesses, endocarditis, osteomyelitis and subcutaneous abscesses. Infectious shock is less common. 2.Epizootic sepsis Most commonly seen in hospital infection, when the patient receives broad-spectrum antibiotic treatment, this bacteria is easy to form drug-resistant strains, the number of this bacteria in the respiratory tract and intestinal tract increased significantly, can lead to systemic infection, but also common after interventional treatment, such as artificial joints, artificial valves, pacemakers and various catheters left in the case. 3, enterococcal sepsis Enterococcus is an opportunistic infection bacteria, usually mainly in the intestinal tract and urinary system, its incidence has increased in the past 30 years, the clinical performance of urinary tract infection and endocarditis is most common, in addition to meningitis, osteomyelitis, pneumonia, enteritis and skin and soft tissue infections. 4, gram-negative bacillus sepsis gram-negative bacillus sepsis different pathogenic bacteria through different routes into the blood, can cause complex and diverse manifestations, and sometimes these manifestations are masked by the signs and symptoms of the primary disease, poor health status before the disease, most accompanied by the original disease affecting the body’s defense function. Most of the cases are hospital-acquired, with chills, high fever, sweating, and a bimodal fever type, and occasionally a triple fever type, which is rare in sepsis caused by other pathogens and deserves attention. Sepsis caused by E. coli, alkali-producing bacteria, etc. can also appear similar to typhoid fever, accompanied by a relatively slow pulse, a few patients may have a temperature does not rise, rash, arthralgia and migratory lesions than in Gram-positive sepsis, but the clinical manifestations of P. aeruginosa sepsis secondary to malignant tumors is more dangerous, the rash can be, heart necrotic, about 40% of patients with Gram-negative bacillus sepsis can occur infectious Shock can occur in about 40% of patients with Gram-negative bacillary sepsis, and is more likely to occur in those with hypoproteinemia. Severe cases can appear multi-organ functional damage, manifested as arrhythmia, heart failure; jaundice, liver failure; acute renal failure, respiratory distress and DIC, etc. 5, anaerobic bacterial sepsis The pathogenic bacteria 80%-90% is fragile bacilli, in addition to anaerobic streptococci, peptic cocci and aerobic bacilli, etc., the invasion route to the gastrointestinal tract and female genital tract, decubitus ulcers, ulcers, the clinical manifestations and aerobic bacterial sepsis is similar, its characteristic manifestations are: jaundice incidence of up to 10%-40%, may be related to the endotoxin of bacilli directly on the liver The incidence of jaundice is as high as 10%-40%, probably related to the direct action of endotoxin of B. pneumoniae on the liver and the hemolytic effect of a toxin of B. aerogenes; the secretion of local lesions has a special putrid odor; it easily causes septic thrombophlebitis and migratory lesions in the chest, lung, endocardium, abdomen, liver, brain and bone and joint, which are more common in B. fragilis and Streptococcus anaerobicus sepsis; more severe hemolytic anemia and renal failure can occur in B. aerogenes sepsis, and local migratory lesions In the gas formation, anaerobic bacteria often together with aerobic bacteria into plural bacterial sepsis, the prognosis is dangerous. 6, fungal sepsis generally occurs in the late course of serious primary disease, often suffering from liver disease, kidney disease, diabetes, hematological disease or malignant neoplasm of chronic patients or serious burns, heart surgery, organ transplant patients, they have a long history of application of broad-spectrum antibiotics, adrenal corticosteroids and (or) anti-tumor drugs, so patients suffering from this disease are almost all the organism defense function is low The incidence of the disease has been increasing in recent years. The clinical manifestations of fungal sepsis are approximately the same as those of other sepsis, and most of them are accompanied by bacterial infections, so the symptoms of toxemia are often masked by the presence of concurrent bacterial infections or primary symptoms, and it is not easy to make a clear diagnosis at an early stage.