Vulvar leukoplakia can cause local hypopigmentation of female vulva, abnormal itching of vulva, and some vulvar leukoplakia can become cancerous. At present, the causes of vulvar leukoplakia are clinically considered to be the following: First, long-term chronic inflammatory stimulation. Inflammation of vulva and vagina can cause the epithelium of vulvar mucosa to become hyperplastic, edematous and congested. Under the stimulation of long-term chronic inflammation, local pigment degeneration may occur in the vulva, secondary to vulvar leukoplakia. Secondly, the autoimmune system decreases. Normal female vulva and vagina have self-defense function, can resist external and internal pathogenic microbial interference. When women’s body resistance decreases, it can trigger the local epithelial defense function of vulva to decrease. This can lead to the occurrence of vulvar leukoplakia. Third, genetic factors research shows. Vulvar leukoplakia has a certain degree of genetic factor, but this genetic factor is not 100% inherited. But this genetic factor is not 100% hereditary, only in the process of the onset of vulvar leukoplakia, the genetic factor has a certain influence. At present, there is no specific treatment for pemphigus vulvae, so prevention of pemphigus vulvae is crucial. As mentioned above, the causes of vulvar leukoplakia include chronic inflammatory stimulation, weakened body resistance and genetic factors.