Vulvar leukoplakia refers to a group of vulvar skin, mucous membrane nutritional disorders caused by tissue degeneration and pigmentation changes in the disease, clinically the skin and mucous membrane whitening, coarsening or atrophy of vulvar lesions collectively referred to as “vulvar leukoplakia”, the International Society for the Study of Vulvovaginal Diseases will be renamed “chronic vulvar dystrophy”. “The cancer rate of this disease is not high, most of them are non-cancerous pre-cancerous lesions, only 3%-5% may develop into cancer. The exact cause of the disease is still unclear, except for systemic factors, the local environment of the vulva, humidity, heat stimulation, local physical stimulation, inflammation stimulation and other factors may be the cause of the disease. Common factors are as follows: 1. Inflammatory stimulation: it is the main cause of vulvar leukoplakia, which accounts for about 50% of the patients, and there are a lot of factors causing vulvar infection and inflammatory stimulation. For example, poor hygiene habits, wearing chemical fiber underwear, unclean sanitary products, long-term infection and stimulation will cause skin and mucous membrane damage, inflammatory edema and gradually develop into vulvar leukoplakia. 2.Endocrine disorders: endocrine diseases are caused by endocrine disorders due to pathological perversions of endocrine glands and tissues themselves, or due to genetic enzyme defects and immune functions. Through the determination of tritium(h3)-labeled thymine, it is believed that there exists a kind of protein hormone (called inhibin) in the dermis that can inhibit the growth of epidermal cell division and act only locally in the epidermis with tissue specificity, which makes the local connective tissue hyperplasia and stimulation of metabolism of the epidermis in the place to be disordered leading to vulvar leukoplakia. 3, genetic factors: vulvar leukoplakia patients about 10-30%, is due to genetic causes. Genetic cause of vulvar leukoplakia is mainly atrophic type, and the patients are mainly young girls. Clinical patients under 15 years old should pay attention to the genetic factor firstly and inquire whether there are patients with vulvar leukoplakia in their parents’ family. 4, other diseases: such as diabetes, vitiligo, vulvar eczema, vulvar itching, etc., such as indiscriminate use of drugs, improper treatment, may also lead to or aggravate the formation and development of leukoplakia. According to the clinical manifestations of three types: 1, proliferative vulvar dystrophy occurs in 30-60 years old women, vulvar itching is the main symptom, especially in the evening itching is aggravated, often due to scratching can be caused by redness, swelling and ulceration and pain, burning and other discomforts, the lesion area skin appears to be like the leathery skin bulge, with folds or scales, generally no atrophy or adhesion, the local appearances of mild hypo-pigmentation, mainly affecting the labia, interlabial furrow, and the skin of the labia, the skin of the labia, the skin of the labia. It mainly affects the labia majora, interlacrimal sulcus, clitoris and posterior commissure. 2, sclerosis moss type vulvar dystrophy can be seen at any age, most common in women around 40 years old, early no symptoms, some patients have mild itching, no white lesions, gradually vulva can appear skin mucosa atrophy, whitening, dry and easy to crack, and loss of elasticity, the late skin is thin, the vaginal opening contracture narrowing of the difficulty of sexual intercourse. Young girls often feel vulvar and perianal discomfort after urination or defecation, and the local skin can be seen to appear lock-hole pearl yellow patchy white lesions, which can disappear by themselves in puberty. 3.Mixed vulvar dystrophy When the condition of patients with hyperplastic and atrophic type of vulvar leukoplakia develops to the late stage, generally there will be mixed symptoms of the two types. The treatment of vulvar leukoplakia is divided into the following aspects: 1, it is very important to keep the vulvar skin dry and clean, avoid scrubbing with stimulating drugs, avoid self-scratching, do not eat spicy or stimulating food; 2, if the itching is intense, the lesions for hyperplasia type, can be appropriate topical corticosteroids ointment, but does not advocate oral, and also does not advocate the long-term use of the symptomatic relief can be discontinued; for the keratotic hyperplastic type of skin lesions localized Can choose 0.05% retinoic acid ointment; 3, sclerosis moss type lesions can be used 2% testosterone propionate cod liver oil ointment, 3-4 times a day, until the skin softening, adhesion relaxation and itching eliminated until, due to the external medicine, will not cause patients with masculinization; 4, in the use of the above topical drugs at the same time, if the itch is still intolerable oral antihistamine or sedative medications to stop the itch 5, for the long term not healing of the Patients, there is a tendency of malignant transformation, can choose surgical excision treatment; 6, emotional regulation, Chinese medicine believes that the perineum for the liver meridian walking region, the liver main excretion and emotional regulation is closely related, daily life, patients due to work pressure, emotional fluctuations and other reasons will cause liver depression, plus, the onset of this disease age in the menopausal women, the decline in hormone secretion levels, often accompanied by distraction, emotional instability, etc., these emotional changes also have a strong influence on the development of the disease, the patient’s health. These emotional changes also promote the development of the disease, so in addition to the above medication, emotional regulation is also particularly important in the prevention and treatment of this disease.