Vulvar leukoplakia is a kind of lesion of pigment change and skin cell degeneration in vulvar skin and mucous membrane tissues that occurs in women’s vulva. Because the vulva presents localized whitening in the early stage, many people think it is vitiligo and don’t care about it, and often go to the hospital very late. In fact, there are many vulvar diseases in women, once there is discomfort, you should go to the hospital as soon as possible. Women’s vulvar leukoplakia manifests the most is the first itching, paroxysmal, gradually itchy unbearable, slowly localized skin thickening or atrophy, especially the labia minora or labia majora slowly atrophy and disappearance, serious clitoris will also atrophy and become smaller and disappear, vaginal opening becomes small, dry, first began to have sexual intercourse is painful, and later on sexual intercourse will be very difficult. Early some people local vulva or labia skin white, slowly have atrophy, this is a non-tumor development of the skin disease, there are a lot of medical terms: such as vulvar leukoplakia, vulvar leukoplakia, vulvar dystrophy and so on. This disease manifests itself most often as a form of sclerosing atrophic lichen planus and vulvar squamous epithelial hyperplasia. Some people diagnose it as leukoplakia vulvae, leukoplakia vulvae, vulvar dryness, neurodermatitis, hyperplastic or atrophic vulvitis, sclerosing atrophic tinea, etc. The name of the disease is confusing and is now uniformly called vulvar chronic dystrophy. Some people may ask: what is the cause of female vulvar leukoplakia? In fact, the cause of this disease is not clear, some younger women may be related to genetic factors, especially women prone to vulvar sclerosis and atrophy. Most of them may be related to female endocrine disorders, especially sex hormone level disorders, sex hormone deficiency or sex hormone receptor decline; poor hygiene habits, like to wear chemical fiber underwear or tight underwear, local hygiene products are not clean, local skin or mucous membrane epidermis is stimulated, so that the local oxygen supply is insufficient and other factors. Female vulvar leukoplakia often has itching in the early stage, and it should be differentiated from some infectious skin diseases of vulva or vagina, such as trichomonas or mycosis vaginalis, while candida vaginitis or trichomonas vaginitis is often locally moist, with impregnated whitish white patches, the secretion will be more, and there will be more local burning sensation, tingling, etc. At this time, it is best to go to the hospital to check fungus or trichomonas, and so on, it is good to be differentiated; however, if accompanied with this kind of trichomonas or fungal infections, the vulvar The itching and skin and mucous membrane breakage will be aggravated in people with leukoplakia, and there may be different degrees of localized skin and mucous membrane hypopigmentation, and some people will have edema, skin fissures and scattered superficial ulcers. Some women develop vitiligo, albinism or sclerosis of the vulva, and some older women will have physiologic atrophy of the vulva or atopic vulvitis, which can be identified by Wood’s lamp, skin microscopy or skin biopsy. If the vulvar skin is thickened and itchy, some of them are neurodermatitis or eczema, and if they are white, it is better to cut a piece of them down for pathological examination, which on one hand confirms the diagnosis, and facilitates the early and active treatment, and on the other hand, avoids the occurrence of possible localized skin cancer. For patients with vulvar leukoplakia, they should pay attention to keep the vulva clean and dry, avoid stimulating drugs or soap to wash the vulva, do not wear breathable chemical fiber panties and tight pants, forbidding spicy stimulation of allergic food, such as itching obviously, can be added with sedative, sleeping and anti-allergic drugs. Patients should have an optimistic mindset, actively go to regular hospitals for treatment, regular follow-up, most of them still have a way to cure or significantly improve, do not listen to the so-called targeted genes and other marvelous treatments. There are many ways to treat vulvar leukoplakia, for vulvar sclerosing moss commonly used drugs are tacrolimus ointment, bimatoprost ointment, pyruvic acid ointment, compound vitamin A ointment and progesterone ointment, etc., glucocorticoid hormone ointment or immunotherapy is also effective, and clinically often tacrolimus ointment is used in conjunction with hormone ointment. Drugs can improve the symptoms, early can also be cured, need long-term medication. Young girls sclerosing moss to puberty may be self-healing, generally do not use pyruvate ointment treatment to avoid masculinization. 0.03% or 0.1% tacrolimus ointment or 0.3% progesterone ointment can be applied, the condition can be significantly relieved, but long-term follow-up is required.