According to statistics, China’s population hepatitis B surface antigen carrier rate of 7.18%, hepatitis B virus carriers about 93 million people, some data show that 55% of chronic hepatitis B virus carriers liver pathology has obvious abnormalities, and some of them will develop into chronic hepatitis B, cirrhosis, liver cancer, so it is very important to strengthen the self-management of hepatitis B virus carriers. The first category is “chronic HBV carriers”: serum hepatitis B virus surface antigen (HBsAg) and hepatitis B virus DNA (HBV DNA) positive, hepatitis B virus e antigen (HBeAg) or hepatitis B virus antibody (anti-HBe) positive, with more than 3 consecutive follow-ups within 1 year, and more than 3 consecutive follow-ups within 1 year. If there are more than 3 consecutive follow-up visits within 1 year, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) are in the normal range, and there is no obvious abnormality in liver histology, most of the patients are in the immune-tolerant stage. The second category is “inactive HBsAg carriers”: serum HBsAg-positive, HBeAg-negative, anti-HBe-positive or negative, HBV DNA is undetectable (PCR method) or lower than the lowest limit of detection, with more than 3 consecutive follow-up visits within 1 year, and ALT is in the normal range. Second, self-management measures for hepatitis B virus carriers: 1, regular follow-up: chronic HBV carriers do not need antiviral treatment for the time being, but biochemistry, virology, alpha-fetoprotein and imaging should be performed every 3-6 months. Liver histology is strongly recommended to determine whether they are on antiviral therapy for those >40 years of age, especially for males or those with a family history of HCC, even if ALT is normal or mildly elevated. Inactive HBsAg carriers generally do not need antiviral treatment, but biochemistry, HBV-DNA, alpha-fetoprotein and liver ultrasound should be performed every 6 months. 2, do not treat indiscriminately: Hepatitis B virus surface antigen positive annual natural conversion rate of only about 2%, so do not believe in “conversion ads”, “biased formula”, “secret formula”, blindly pursue surface antigen conversion, do not pursue the surface antigen, do not want to be a victim of the disease, do not want to be a victim of the disease. Therefore, do not believe in “conversion advertisements”, “biased prescription”, “secret formula”, blindly pursuing surface antigen conversion, do not abuse drugs, aggravate the burden on the liver. 3.Combination of work and rest, optimism: Hepatitis B virus carriers should pay attention to the combination of work and rest, eliminate stress, absolutely abstain from alcohol, reasonable diet, balanced nutrition, avoid staying up late, and consume more food rich in high quality protein, such as vegetables, milk, eggs, fish, lean meat, soybean products and so on. 4, develop good living and hygiene habits, pay attention to personal hygiene and public health, the use of razor facial tools, toothbrushes, toiletries and healthy people separate. To prevent mother-to-child vertical transmission, newborns of HBsAg-positive mothers should be injected with hepatitis B immunoglobulin (HBIG) as early as possible within 24 h after birth (preferably 12 h after birth) at a dose of ≥100 IU, and at the same time, they should be inoculated with 10 μg of recombinant yeast or 20 μg of Chinese hamster oocyte (CHO) vaccine against hepatitis B in different parts of the body, and then the second and third injections of HBIG at the age of 1 month and 6 months respectively. Hepatitis B vaccine was administered at 1 month and 6 months of age for mother-to-child interruption.