The vaginal opening of a lump is mainly considered to be caused by vestibular gland cysts, folliculitis, condyloma acuminata, etc. Malignant vaginal masses also need to be ruled out, and the type of disease needs to be diagnosed and treated in a timely manner based on clinical manifestations and examinations. Common causes and treatments 1, vestibular gland cysts: cysts are hard and can be painful when infected, and even localized pus. The clinical finding of a hard mass and relatively small, you can temporarily do without treatment, daily life pay attention to keep the vulva clean. If the cysts are large, surgery is recommended; 2, condyloma acuminata: due to human papillomavirus infection caused by wart-like damage, no obvious symptoms, no pain, no itch, to anti-viral treatment and laser treatment; 3, folliculitis: the performance of the hair follicle as the center of the red papules, sometimes topped with white pustules, there may be itching, tenderness or pain, the location of deep folliculitis pain more obvious, according to the symptoms and auxiliary examination, the application of antibiotics. The boils are painful, red or edematous, and need to be treated with povidone iodine solution in a sitz bath or rubbed on the affected area, and then rubbed with erythromycin ointment; 5. Malignant tumors: squamous cell carcinoma of vulva is the most common, accounting for 90% of vulvar cancer, and the rest include melanoma of vulva, basal cell carcinoma of vulva, adenocarcinoma of vestibule, etc. Biopsy is needed to clarify the nature of specific masses for targeted treatment. It is recommended not to use irritating bathing liquid or medicine to clean the vulva, keep it clean and dry, and wear cotton underwear to keep it dry and breathable. Topical contact medications should be avoided for private use and should be examined at a hospital and used correctly under the guidance of a doctor.