Gout patients often ask whether they should use drugs that promote uric acid excretion or drugs that inhibit uric acid synthesis. Or should I use a drug that inhibits uric acid synthesis? How can you tell if you have a uric acid excretion problem or a production problem? Here is a brief introduction to several common methods of determining: 1. 24-hour uric acid measurement: 24-hour urine collection is required to detect the uric acid content in urine. The uric acid excretion is less than 800mg/d (3.6mmol, normal diet) or less than 600mmol (4.8mmol, low purine diet), which belongs to poor excretion type; anyway, uric acid excretion in urine is more than 800mg/d or 600mmol/d, which belongs to excessive production type; of course, there are some patients belong to mixed type. 2.Random urine uric acid/creatinine ratio: If it is greater than 1.0, it belongs to overproduction type; if it is less than 0.5, it belongs to poor excretion type; 3.Urinary PH method: it is the easiest preliminary inference method in clinic (but it is affected by more factors): the normal reference value of urinary PH is 5.0-7.0; when urinary PH is <5.5, it may be caused by the increase of uric acid concentration, which indicates the increase of uric acid production in the body; when urinary PH is normal or high, it indicates the increase of uric acid production in the body; when urinary PH When urine PH is normal or high, it indicates that uric acid excretion is low. The above method is only a general assessment of uric acid production and excretion in the body, but the doctor will also make a specific individualized plan according to the patient's specific conditions, such as liver and kidney function, comorbidities, dietary habits, past history, presence of kidney stones, allergy history, etc.