Adenocarcinoma is the abbreviation of glandular epithelial carcinoma, which is a malignant tumor formed by glandular epithelium, commonly found in the gastrointestinal tract, but also in the breast, ovary, uterus, lung, kidney and various endocrine and exocrine glands. When the cavity of the gland is highly inflated and cystic, it is called cystic adenocarcinoma, and those with papillary growth can be called papillary cystic adenocarcinoma. The symptoms of adenocarcinoma mainly depend on the location of the tumor. Adenocarcinoma often shows symptoms such as persistent and irritating choking cough, sputum with blood spots or a small amount of blood, chest tingling or chest tightness with sputum, etc. If the tumor is large, compression symptoms may appear, such as ipsilateral diaphragm palsy (compression of phrenic nerve), pleural shortness of breath (invasion of pleura), head and face swelling, venous anger (compression of superior vena cava), limb numbness, facial sweating, swelling, eyelid drooping (compression of brachial plexus nerve). (compression of brachial plexus nerve). The most common sites of metastasis are brain, bone, liver and adrenal gland. Brain metastases may cause intracranial hypertension and localization symptoms, including headache, vomiting, blurred vision, vertigo, weakness of one limb, ataxia, etc. Localized pain, fractures and hypercalcemia may occur in bone metastases. Liver metastases may include anorexia, liver pain, hepatomegaly, jaundice, and ascites. Adrenal metastases may present with high blood pressure or no symptoms at all. In addition, adenocarcinoma can also metastasize to the lymph nodes on the surface of the body, the most common being bilateral supraclavicular lymph node metastasis, which can appear as a local mass but is not painful or itchy, and is mostly discovered unintentionally. Choking cough Over 40 years old, unexplained and persistent irritating choking cough is often the early aura of adenocarcinoma, especially central type is more important because of spasmodic contraction of large airways stimulated by cancer tumor, so central type lung cancer discloses its aura signal much earlier than peripheral type lung cancer. Chest pain is also an early signal, with sharp stabbing pains, which appear earlier in undifferentiated lung cancer. Hemoptysis is an early sign of central lung cancer because of the rich distribution of blood vessels in the tracheal mucosa, but the blood is very small, while peripheral lung cancer is more distant from the trachea, so hemoptysis usually appears later. Lung adenocarcinoma will show unexplained hypothermia, especially intermittent fever (reported to be 70%), and with the above symptoms, it should be taken seriously. The symptoms include irritating choking cough, change in cough pattern in primary bronchitis, or persistent cough that does not resolve after more than three weeks of treatment.