The main symptom of duodenal ulcer is pain in the upper abdomen. Typical pain occurs in the fasting state and can be relieved by eating, or by eating alkaline foods such as soda crackers. The typical patient’s abdominal pain tends to have a seasonal pattern, occurring in the fall, winter, or winter-spring, and it is common for the pain to recur and resolve over many years, known as “cyclic” pain. It may resolve on its own. The pain worsens with alcohol consumption or uncontrolled diet. It may worsen with stress and exertion. The pain is mostly burning or dull and “rhythmic”, i.e. “pain – eating – relief”. The pain can sometimes be radiated to the corresponding area of the back. It may be accompanied by acid reflux, vomiting, and gastric distention. In some patients with duodenal ulcers, gastrointestinal bleeding occurs when the ulcer erodes the blood vessels. Ulcers are the most common cause of upper gastrointestinal bleeding in humans, and bleeding can occur with vomiting of blood, black stools, etc., requiring emergency treatment. In severe cases, perforation may occur, and sudden onset of severe abdominal pain, which is unbearable, also requires emergency treatment. Some patients present with bleeding and perforation on the first ulcer episode. A small number of patients with duodenal ulcers have no symptoms and are “silent ulcers”. These ulcers are more likely to develop complications. The treatment of duodenal ulcers can be tailored to their cause. Most patients with duodenal ulcers are found to be infected with H. pylori, a bacterium that settles in the stomach but can cause duodenal ulcers through a series of complex mechanisms, so patients with duodenal ulcers, whether active or scarred, must be tested for H. pylori and, if positive, receive standardized relevant antimicrobial therapy. If H. pylori is successfully eradicated, the ulcer can be cured and recurrence of the majority of ulcers can be eliminated. Another reason for the development of duodenal ulcers is the use of non-steroidal anti-inflammatory drugs such as aspirin. Such patients need to stop taking the drugs as much as other conditions allow and take drugs that inhibit gastric acid secretion, such as omeprazole, which can basically heal in 4 to 8 weeks of treatment. However, such patients also need to be checked for the presence of H. pylori infection. Of course, there are other rare causes of duodenal ulcers, such as endocrine tumors, which are more specific and require targeted treatment. Therefore, when patients have the above symptoms of duodenal ulcer, they must pay attention to it, go to the hospital for examination and treatment according to the etiological condition in a timely manner.