Patients with duodenal ulcers have certain occupational tendencies, such as automobile drivers, long-term field lodgers, workers in cold areas or plateaus with hypoxia, and brain workers, who are prone to this disease. The pathogenesis has not been fully elucidated, it may be that the characteristics possessed by these occupations, from different angles, are more likely to destroy the gastric and duodenal mucosal barriers, so susceptible to duodenal ulcers. For example, car drivers are more prone to duodenal ulcers because of their work characteristics, irregular diet and overeating; brain workers, who are in a state of chronic mental stress and excitement, also have more duodenal ulcers than other occupations. But the occupational factors are not absolute, as long as the proper prevention, life and work regularity, can prevent the occurrence of duodenal ulcers. Therefore, the characteristics of different occupations should be identified from its regularity, to prevent. For example, drivers should pay attention to the regularity of meal times, avoiding long periods of fasting and overeating, while brain workers should ensure a combination of work and rest and strengthen physical exercise. After these people with occupational characteristics suffer from duodenal ulcer, there is nothing special in its treatment, but the patient must be guided to overcome the unfavorable factors of occupation while treating and preventing duodenal ulcer, only in this way can we receive satisfactory results in treatment and prevention. How to prevent the recurrence of bulbar ulcer disease? It has to start with the occurrence of ulcer disease. In recent times, it is believed that ulcer disease is mainly caused by the attack of gastric acid and pepsin on the mucosa of the bulb, and the attack of the former exceeds the defense of the latter. Modern ulcer treatment strategies have focused on both reducing gastric acid secretion and improving mucosal resistance to attack. Patients with HP (Helicobacter pylori) positive bulbar ulcers can be treated with H2 receptor orthodontic agents combined with antibacterial agents (e.g. gentamicin oral tablets, metsulin-S granules, colloidal bismuth); patients with HP negative bulbar ulcers can be treated with Hz receptor blockers combined with mucosal protective agents (e.g. aluminum thioglycollate). Refractory duodenal ulcers can be treated with the proton pump inhibitor Loxac for 4 to 6 weeks. The above combination of drugs is beneficial in reducing the recurrence rate of bulbar ulcers.