The ability to take medication for bleeding duodenal ulcers depends on the clinical manifestations of the bleeding. If the bleeding is more serious in terms of symptoms, with obvious vomiting of blood and black stool, or even abnormal vital signs in some patients, then oral medication cannot be taken, and instead, immediate hospital visits are required for cardiac monitoring, the use of intravenous PPI injections, and symptomatic treatment such as hemostasis and rehydration. Only when the symptoms are well controlled and there are no more obvious clinical symptoms of vomiting blood and black stool, it is recommended that duodenal ulcer patients use oral acid-suppressing PPI preparations to achieve inhibition of gastric acid secretion to improve bleeding and treat duodenal ulcer at the same time.PPI acid-suppressing therapy is one of the most effective drugs we can use in duodenal ulcer, even when accompanied by bleeding, and its main mechanism is by inhibiting gastric acid and pepsin activity, thus interfering with the endo-exogenous coagulation system, inhibiting platelet factor activity and platelet aggregation, and raising the pH level in the stomach. When the pH value exceeds 6, it is the most powerful measure to promote platelet aggregation and improvement. In addition to PPI preparations, later for patients with duodenal ulcer with bleeding, it is also possible to add mucosal protective agents to symptomatic treatment along with PPI use, and the effect will be more satisfactory.