Helicobacter pylori or H. pylori, or Hp for short, is a Gram-negative, microaerobic bacterium that lives in various areas of the stomach and duodenum. It can cause minor chronic inflammation of the gastric mucosa, or even lead to gastric and duodenal ulcers and gastric cancer, according to statistics, the global population infection rate is about 60%, divided into different strains, but currently there are no clinical conditions to distinguish between the infected strains. Currently there are three methods of examination: 1, blood sampling to measure the level of relevant antibodies. 2.Carbon breath test on an empty stomach. 3, gastroscopy in the gastric sinus to take a small piece of biopsy for rapid urease test. At present, the carbon breath test is the most simple, feasible, non-invasive and accurate test. So do many patients who find this infection during physical examination actually need to be treated? Previous globally accepted guidelines suggest that eradication is required in the presence of: 1. a family history of gastric cancer 2. Gastric or duodenal ulcers. 3. Severe gastritis. 4. Refractory iron deficiency anemia. 5.Frequent episodes of urticaria. 6.Gastric mucosa-associated lymphoma. So, eradication used to be indicated. However, the changes that occurred in the global guidelines in 2014, the latest Kyoto guidelines concluded that the bacterium is infectious and needs to be completely eradicated, so it was recommended that anyone found to be infected needs to be eradicated as long as there are no obvious contraindications. Therefore, the clinic entered a period of confusion as to what should be done, so currently, in addition to the above indications, the patient’s wishes are important.