Headache is divided into primary headache and secondary headache, and the principles of medication for different types of headache are different. For example, for primary headache such as migraine and tension headache, the medication is based on non-steroidal anti-inflammatory drugs, opioids, ergot preparations and treprostin, and the commonly used drugs include celecoxib, ibuprofen, diclofenac sodium, tramadol, nicergoline and zolmitriptan. For example, headache caused by encephalitis should be treated with antiviral, antibacterial and glucocorticoids to reduce headache, while headache caused by cerebrovascular disease, such as traumatic brain injury, brain tumor and other causes of cranial hypertension, mainly choose mannitol, furosemide, albumin and other dehydrating and cranial pressure-lowering drugs to relieve headache.